A new pattern in hepatitis A virus infection in an urban population.

A new pattern in hepatitis A virus infection in an urban population. Rev Esp Enferm Dig. 2020 Feb 21;112: Authors: Martínez Lozano H, Conthe Alonso A, Bañares R Abstract INTRODUCTION: hepatitis A virus (HAV) infection is a common cause of acute hepatitis worldwide. Since the generalization of vaccination, its incidence had markedly declined. Nevertheless, several HAV-outbreaks have been described in the last decade, mainly related to contaminated alimentary products. In recent years, a new pattern of acute HAV infection has been described with changes in the demographic profile of the infected population, which is more common in healthy young men. PATIENTS AND METHODS: a retrospective case series study was performed to evaluate this possible change in the pattern of HAV infection. The case series included all patients with a diagnosis of HAV acute infection in our hospital between January 2005 and May 2017. RESULTS: a total of 196 cases were diagnosed which were comprised of two probable outbreaks: one starting in November 2008 of 26 cases and one starting in 2016 with 69 cases at the time of data collection. The two outbreak populations were comparable. While the sporadic cases group was predominantly formed by pediatric and third-age patients with a slight male tendency, the outbreak related cases showed a clear predominance for young males (proportion of males: 63.2% vs 85.3%, p
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

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Contributors : Christine Yu ; Kaoru Hida ; Efstathia PapafragkouSeries Type : Expression profiling by genome tiling arrayOrganism : Allium fistulosum ; Apium graveolens ; Astrovirus sp. ; Bacillus subtilis ; Coxsackievirus ; Hepatitis E virus ; Hepatovirus A ; Norovirus ; Rotavirus ; Sapovirus ; Solanum lycopersicum ; unidentified adenovirusThe capability of the U.S. Food and Drug Administration Enteric Viruses tiling microarray (FDA-EVIR) was assessed for rapid molecular identification of human norovirus (NoV) and hepatitis A virus (HAV) extracted from artificially inoculated fresh produce. Two published viral extraction ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by genome tiling array Allium fistulosum Apium graveolens Astrovirus sp. Bacillus subtilis Coxsackievirus Hepatitis E virus Hepatovirus A Norovirus Rotavirus Sapovirus Solanum lycopersicum unidentified adenovir Source Type: research
virus (HAV) is a positive-strand RNA virus that is transmitted feco-orally through person-to-person contact. Outbreaks are often linked to poor sanitation, overcrowding, or food and water contamination. Infection is often asymptomatic in children, but adults present with jaundice, abdominal pain, hepatitis, and hyperbilirubinemia. Diagnosis is through detection of immunoglobulin M antibodies against HAV, and treatment is supportive. Vaccination is the mainstay of prevention and should be given before exposure whenever possible.
Source: Gastroenterology Clinics of North America - Category: Gastroenterology Authors: Source Type: research
Abstract The numerous recent hepatitis A outbreaks emphasize the need for vaccination; despite the effectiveness of the current ones, developments are needed to overcome its high cost plus some immune response limitations. Our study aims to evaluate the use of chitosan and alginate-coated chitosan nanoparticles as an adjuvant/carrier for the hepatitis A vaccine (HAV) against the traditional adjuvant alum. Immune responses towards (HAV-Al) with alum, (HAV-Ch) with chitosan, and (HAV-aCNP) with alginate-coated chitosan nanoparticles, were assessed in mice. HAV-aCNP significantly improved the immunogenicity by increa...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
The rise of vaccine-preventable illnesses, such as measles and hepatitis, in the United States and around the globe has been alarming in recent years. For women — especially those hoping to become pregnant, as well as women who are pregnant or have recently had a baby — vaccines can be a worrisome topic. There are many misconceptions about vaccine safety in and around pregnancy that can lead to confusion and unnecessary fear of a lifesaving medical tool. As a practicing ob/gyn, I often discuss vaccines with my patients and help them sort out fears versus facts. Which vaccines should you consider before concepti...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Parenting Pregnancy Vaccines Women's Health Source Type: blogs
Wang Dabing Zhang Among the causative agents of duck viral hepatitis, duck hepatitis A virus genotype 1 (DHAV-1) is the most common virus reported in most outbreaks worldwide. How to propagate DHAV-1 in cell cultures efficiently remains a problem to be explored. Here, we aimed to test the effect of serum type on DHAV-1 replication in duck embryo fibroblast (DEF) cells. Comparative studies involved virus culture and passage, observation of cytopathic effect (CPE), virus quantification, and plaque formation assay. From the results of these investigations, we conclude that use of chicken serum (CS) in maintenance medium...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
After facing a major outbreak last year, Florida had 32 reported cases of hepatitis A during the first four days of 2020, state Department of Health numbers show. Duval County led the state in the number of newly reported cases from last Wednesday to Saturday, with five, followed by Polk County, which had four cases. Totals posted on the  Department of Health website showed that 3,396 cases of hepatitis A were reported to the state in 2019, up from 548 c ases in 2018. Hepatitis A can cause liver…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Source Type: news
Abstract In 2018, a hepatitis A virus outbreak was identified among internally displaced persons in Syria. Sequence analysis based on the viral protein 1/2 junction revealed that the causative virus belonged to genotype IB. A high displacement rate, deteriorated sanitary and health conditions, and poor water quality likely contributed to this outbreak. PMID: 31829918 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Foodborne Pathogens and Disease, Ahead of Print.
Source: Foodborne Pathogens and Disease - Category: Food Science Authors: Source Type: research
M. Kaddoura et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Hepatitis A Outbreak in Six States Linked to Fresh Blackberries There have been 18 illnesses in six states in a hepatitis A outbreak possibly...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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