Immunogenicity and Safety of 23-Valent Pneumococcal Polysaccharide Vaccine in Healthy Volunteers Aged 2 Years and Above
Condition: Pneumonia, Pneumococcal Intervention: Biological: 23-Valent Pneumococcal Polysaccharide Vaccine Sponsor: Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd Completed
[The Conversation Africa] In 2005, before most low- and middle-income countries started vaccinating children routinely for pneumococcal disease, it caused approximately 1.5 million deaths worldwide annually. About 700,000 to 1 million of these deaths were in children under five years. Pneumococcal disease occurs when Streptococcus pneumoniae invades a normally sterile area of the body, causing meningitis, pneumonia, septicaemia or other disease syndromes. Case fatality rates are very high for septicaemia (>20%) and meningitis (&
CONCLUSIONS: IPD required PICU admission in cases of septic shock and meningitis, and less so with complicated pneumonia. The percentage of admissions is greater in children with an underlying disease. Admission into the PICU involves a longer stay, complications during the acute phase, as well as sequelae, particularly neurological ones. The serotypes of the patients that were admitted to PICU were predominantly vaccine serotypes. PMID: 32998844 [PubMed - as supplied by publisher]
ConclusionsVaccination rates among Canadian patients with RA are suboptimal.
(Murdoch Childrens Research Institute) A pneumococcal vaccine was effective at protecting children in Laos against the most severe type of pneumonia, a new study has found.
Abstract Pneumococcal disease is a substantial contributor to illness and death in young children globally. The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000 had a significant impact in preventing pneumococcal disease in both vaccinated children and unvaccinated individuals (through herd effect). A higher valent PCV13 replaced PCV7 in late 2009. This analysis was undertaken to assess how many cases and deaths have been averted over the last decade since PCV13 introduction. A model estimated the number of infants vaccinated annually with PCV13, as well as the number of cases and deaths of i...
CONCLUSIONS: Clinic control analyses show PCV10 prevented radiographic pneumonia in Bangladesh, especially among younger children receiving three doses. While both analyses were underpowered, community control enrollment - compared to clinic controls - was more difficult in a complex, pluralistic healthcare system. Future studies in comparable settings may consider alternative study designs. PMID: 32873404 [PubMed - as supplied by publisher]
Abstract The current integrative review aimed to explore the extent to which pneumococcal pneumonia impacts the Veteran population and strategies to increase pneumococcal vaccination in this population. The search strategy began with three electronic databases (CINAHL, PubMed, and Embase). After analysis of 50 studies, considering inclusion and exclusion criteria, nine studies were selected for final analysis. Three primary themes emerged from the literature: (a) decreased 1-year morbidity and mortality in Veterans with comorbid conditions who received pneumococcal vaccination, (b) significant barriers in outpatie...