End of dose interval symptoms in patients treated with natalizumab: a role for serum cytokines?

ConclusionIn our study EDI symptoms could not be objectified since EDI and non-EDI groups did not differ in terms of change in mood, cognition and fatigue between day 0 and 7 suggesting that symptom recrudescence could be a subjective experience. Although our results need to be interpreted cautiously, we found no clear correlation between studied serum cytokines concentrations and the occurrence of EDI symptoms.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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The two largest pharmacy benefit managers (PBMs), CVS Caremark and Express Scripts, have once againincreased the number of medicines on their standard formulary exclusion lists. Medicines excluded from formularies treat many chronic and complex conditions, including depression, diabetes and multiple sclerosis. As these PBMs control over half of the market combined, these changes have widespread implications for patients across the country.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Drug Cost Let's Talk About Cost Source Type: news
Background: Sustained cognitive testing is used to detect cognitive fatigability and is often considered a substitute for subjective cognitive fatigue (CF). However, the relationship between cognitive fatigability and subjective CF in people with multiple sclerosis (PwMS) remains undetermined. Objective: To explore potential associations between fatigability induced by sustained cognitive testing and subjective CF in PwMS. Methods: We gave 120 PwMS and 60 demographically matched, healthy individuals the Beck Depression Inventory—FastScreen (BDI–FS) to measure mood and the Modified Fatigue Impact Scale t...
Source: Cognitive and Behavioral Neurology - Category: Neurology Tags: Original Studies Source Type: research
ConclusionModifiable lifestyle factors including healthy diet, increased physical activity and supplement use were associated with higher HRQOL among people with MS. The SF-6D instrument revealed significant discriminatory power in this international cohort of people with MS.
Source: Quality of Life Research - Category: Health Management Source Type: research
CONCLUSION: On the basis of a broadly based research and participatory development process, a set of indicators has been developed that enables comprehensive evaluation of the regional quality of care of cross-indication, integrated care models focusing on common diseases. In order to be able to increasingly evaluate aspects of care coordination and patient orientation, health promotion as well as nursing, palliative and emergency care in the future, it would be helpful if routine data were collected or made accessible in these areas as well. PMID: 32467041 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
ConclusionResilience contributed minimally (but significantly) to healthy aging. Older participants scoring higher on resilience reported healthier lifestyle behaviors (more exercise, better diet) and social/financial support compared to lower scoring respondents. Our findings suggest that self-management programs for older persons with MS should focus on three key factors to foster healthy aging: depression, fatigue and resilience.
Source: Quality of Life Research - Category: Health Management Source Type: research
Gerber Brand Persons with multiple sclerosis (PwMS) often complain about sleep problems. There is less known about objective sleep-electroencephalography (EEG) dimensions within naturalistic conditions (i.e., home and/or familiar setting). The present cross-sectional study examined the associations between objective and subjective sleep, depression, physical activity scores, and MS-related information among PwMS in their familiar setting. The sample consisted of 16 PwMS (mean age: 50.3 years; median Expanded Disability Status Scale (EDSS): 5.5) who completed questionnaires covering subjective sleep (symptoms of ins...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSION: The limited amount of knowledge denotes the need for additional in vitro studies on the combination of rTMS and pharmacotherapy, which could be extended to in vivo studies and ultimately inform the design of clinical trials so as to improve the therapeutic management of patients with a wide array of neuropsychiatric disorders. PMID: 32418533 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
__ FDA Clears Nurocheck, Portable Device to Quickly Assess Brain Health (MS News Today): “A portable device that can quickly measure electrical activity in the brain and relay it to doctors via a smartphone app, called the Nurochek system, has been cleared by the United States Food and Drug Administration (FDA) for use as a medical device. Its developer, Headsafe, plans to it soon make this brain assessment system available for use with patients in the U.S., ages 14 and older.” The Announcement: Headsafe Announces FDA Clearance and U.S. Launch of its NUROCHEK Portable Brain Assessment System (press release): &l...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology 510(k) clearance app brain brain health technology brain-assessment EEG electrical activity FDA Food and Drug Administration Headsafe neurological testing Nurochek portable Source Type: blogs
Conclusions: The prevalence of SC is higher in patients with MS compared to the general population. Their occurrence is mostly influenced by the disease itself (duration, relapses, acquired disability) and also by depression and lack of education. PMID: 32399081 [PubMed - in process]
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
Depression is associated with decreased neuroperformance and increased likelihood of new brain lesions in patients with multiple sclerosis, a new study of more than 2500 participants suggests.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
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