Preimplantation Genetic Testing: ACOG Committee Opinion Summary, Number 799.

Preimplantation Genetic Testing: ACOG Committee Opinion Summary, Number 799. Obstet Gynecol. 2020 Mar;135(3):752-753 Authors: Abstract Preimplantation genetic testing comprises a group of genetic assays used to evaluate embryos before transfer to the uterus. Preimplantation genetic testing-monogenic is targeted to single gene disorders, and preimplantation genetic testing-aneuploidy is a broader test that screens for aneuploidy in all chromosomes, including the 22 pairs of autosomes and the sex chromosomes X and Y. To test embryos that are at risk for chromosome gains and losses related to parental structural chromosomal abnormalities (eg, translocations, inversions, deletions, and insertions), preimplantation genetic testing-structural rearrangements is used. Independent of the preimplantation genetic testing modality employed, false-positive and false-negative results are possible. Patients and health care providers should be aware that a "normal" or negative preimplantation genetic test result is not a guarantee of a newborn without genetic abnormalities. Traditional diagnostic testing or screening for aneuploidy should be offered to all patients who have had preimplantation genetic testing-aneuploidy, in accordance with recommendations for all pregnant patients. It is especially important to offer diagnostic testing or screening for aneuploidy after preimplantation genetic testing-monogenic or preimplantation genetic testing-stru...
Source: Obstetrics and Gynecology - Category: OBGYN Tags: Obstet Gynecol Source Type: research