Effect of HIV-infection on QuantiFERON-Plus accuracy in patients with active tuberculosis and latent infection

It is estimated that one fourth of world population is infected with M. tuberculosis (Mtb) 1-5 and that only the 5-10 % of Mtb-infected individuals will progress to tuberculosis (TB) disease during life time.2,5 In 2017, 1 million (9%) of the worldwide TB cases were related to HIV-infected persons leading to 300,000 deaths.5 HIV-infection is responsible of an increased risk of progression to active disease, representing one of the main cause for active-TB disease, even in the absence of a deep CD4 T-cell impairment and even if under antiretroviral therapy (ART).

Source: Journal of Infection - February 21, 2020 Category: Infectious Diseases Authors: Elisa Petruccioli, Teresa Chiacchio, Assunta Navarra, Valentina Vanini, Gilda Cuzzi, Claudia Cimaglia, Luigi Ruffo Codecasa, Carmela Pinnetti, Niccol ò Riccardi, Fabrizio Palmieri, Andrea Antinori, Delia Goletti Tags: Original article Source Type: research