Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronism

Publication date: Available online 22 February 2020Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Martin Wolley, Moe Thuzar, Michael StowasserAbstractAdrenal venous sampling (AVS) is a key part of the diagnostic workup of primary aldosteronism, distinguishing unilateral from bilateral disease and determining treatment options. Although AVS is a well-established procedure, many aspects remain controversial, including optimal patient selection for the procedure and exactly how AVS is performed and interpreted. Despite the controversies, a growing body of evidence supports the use of AVS in most patients with primary aldosteronism, though some specific patient groups may be able to forego AVS and proceed directly to treatment. Although AVS remains a difficult procedure, success rates may be improved with the use of advanced CT imaging techniques and/or rapid cortisol assays. New advances in nuclear imaging and steroid profiling may also offer alternatives or adjuncts to AVS in the future.

Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 23, 2020 Category: Endocrinology Source Type: research