Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells

Conclusion: Our results advance the current mechanistic understanding of the pseurotin-induced inhibition of IgE production in B-cells by linking the effect to STAT signaling, and associated modulation of B-cell proliferation and differentiation. Together with our finding that structurally simpler pseurotin analogs were able to reproduce the effects of natural pseurotins, the presented work has implications for the future research on these secondary metabolites in the context of allergic diseases.Graphical abstact
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research

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Conclusion: Gut microbiota composition and function are associated with CKD severity. And, specific gut microbes are potentially helpful for CKD early diagnosis and prognosis monitoring. PMID: 32241215 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sana Dhaouadi, Leila Soufi, Amani Hamza, Didier Fedida, Chtioui Zied, Emna Awadhi, Mohamed Mtibaa, Bilel Hassen, Ameur Cherif, Carmen Torres, Mohamed Salah Abbassi, Ramzi Boubaker Landolsi
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Herbal MedicineAuthor(s): Mohammad Mehdi Jafarzadeh, Mohammad Javad Mehdipour Moghaddam, Davood Bakhshi
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Abstract Poly(D,L-lactide-co-glycolic) acid (PLGA) is a synthetic copolymer that has been used to design micro/nanoparticles as a carrier for macromolecules, such as protein and nucleic acids, that can be internalized by the endocytosis pathway. However, it is difficult to control the intracellular delivery to target organelles. Here we report an intracellular delivery system of nanoparticles modified with bacterial cytotoxins to the endoplasmic reticulum (ER) and anti-inflammatory activity of the nanoparticles. Subtilase cytotoxin (SubAB) is a bacterial toxin in certain enterohemorrhagic Escherichia coli (EHEC) s...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Publication date: Available online 2 April 2020Source: Food ControlAuthor(s): Manasweeta Angane, Sravani Gupta, Graham C. Fletcher, Graeme Summers, Duncan I. Hedderley, Siew Young Quek
Source: Food Control - Category: Food Science Source Type: research
imarães S Abstract Giardia duodenalis is one of the most important and widespread gastrointestinal parasites in the world. Despite its relevance as a causative agent of diarrhea, asymptomatic giardiasis occurs frequently, especially in low resources settings in which children are exposed to many risk factors. Based on microscopic examination and the polymerase chain reaction (PCR) amplification and sequencing of beta-giardin (bg), triose phosphate isomerase (tpi) and glutamate dehydrogenase (gdh) genes, we assessed G. duodenalis occurrence and genetic diversity in isolates of children attending a daycare ce...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Publication date: Available online 3 April 2020Source: Microbial PathogenesisAuthor(s): González Juliana, Cadona Jimena, Sanso Mariel, Bustamante Ana
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 2 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Pengcheng Du, Dejun Liu, Huangwei Song, Pei Zhang, Ruichao Li, Yulin Fu, Xiao Liu, Jinli Jia, Xiaodi Li, Séamus Fanning, Yang Wang, Li Bai, Hui Zeng
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 3 April 2020Source: Journal of BiotechnologyAuthor(s): Min Liu, Jiali Lou, Jiali Gu, Xiao-Mei Lyu, Feng-Qing Wang, Dong-Zhi Wei
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
AbstractAcute pancreatitis (AP) is termed as idiopathic (IAP) when the underlying conditions of pancreatic inflammation remain unknown. The aim of this study was to identify different clinical features in patients with IAP and AP of known aetiology. All patients hospitalized in our Gastroenterology Unit with an initial diagnosis of AP were recruited. AP was classified as of known aetiology or idiopathic according to clinical examination, serum biochemistry testing, and radiological imaging investigations, and clinical data in both patient groups were compared. A total of 127 patients (80 males, mean age: 57  years) we...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
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