RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma

Lung adenocarcinoma (LUAD) is a common histological type of non-small cell lung cancer (NSCLC), accounting for nearly 40% of all lung cancers [1]. Current research has identified several LUAD-specific oncoproteins with differential expression of wildtype or mutant forms, which includes the REarranged during Transfection (RET) receptor tyrosine kinase (RTK). The expression and activation of RET has been implicated in multiple cancers, including lung [2,3]. RET is expressed at low levels in normal lung tissues, however RET gene rearrangements give rise to chimeric proteins with constitutive kinase activity that drive tumourigenesis in early stage LUADs lacking other oncogenic variants [4].

Source: Lung Cancer - February 21, 2020 Category: Cancer & Oncology Authors: Serisha Moodley, Eric Y Lian, Mathieu J F Crupi, Brandy D Hyndman, Lois M Mulligan Source Type: research