Joint wound healing using polymeric dressing of chitosan/strontium-doped titanium dioxide with high antibacterial activity

Publication date: Available online 22 February 2020Source: Materials LettersAuthor(s): Li Chen, Hong Pan, Caifeng Zhuang, Mengyao Peng, Li ZhangAbstractTreatment against bacterial infection is of great significance for joint wound healing in medical nursing care. Thus, it is urgent to develop efficient antibacterial agent with excellent wound healing capability. In this research, a two-step strategy was employed for the development of novel chitosan scaffold reinforced by strontium doped TiO2 nanoparticles (CS/Sr-TiO2). The antibacterial activity of CS/Sr-TiO2 against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Wound healing properties of CS/Sr-TiO2 were tested in rabbit joint wound, and the Sr-doping is able to achieve a high wound healing rate near 93 % after 12 days. Hence the results strongly demonstrate that the CS/Sr-TiO2 nanocomposites may be the promising materials for wound healing application in nursing care with enhanced antibacterial activity and high biocompatibility.Graphical abstract
Source: Materials Letters - Category: Materials Science Source Type: research