Analysis of variants of AKT1 in schizophrenia multiplex families.

Analysis of variants of AKT1 in schizophrenia multiplex families. Asian J Psychiatr. 2020 Feb 11;49:101957 Authors: Chow TJ, Tee SF, Loh SY, Yong HS, Abu Bakar AK, Tang PY PMID: 32078952 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Related Links:

The advent and application of high-throughput sequencing is revolutionizing our understanding of the molecular neurobiology of diverse psychiatric disorders. Whole-genome sequencing, which targets the coding regions of the genome, and whole-exome sequencing are being applied to study multiple psychiatric disorders, including autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder, schizophrenia, and Tourette ’s disorder, among others [(1–3); https://schema.broadinstitute.org]. These studies have demonstrated a role for ultrarare, deleterious, frequently de novo variation in each disorder, and h...
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Low levels of vitamin D are prevalent among patients with schizophrenia and have been linked to the risk and outcome of the disorder. Vitamin D has a regulatory effect on the inflammatory system, which is dysfunctional in schizophrenia. We investigated the association between serum vitamin D levels, inflammatory status, and severity of schizophrenia symptoms. A total of 39 clozapine-treated schizophrenia patients were recruited to the study. Blood samples for biochemical analysis were collected from all participants. Serum levels of vitamin D and cytokines (IL-4, IL-6, IL-10, and TNF-α) were analyzed and the associat...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
This study, based on the ‘Servizi Territoriali Associati per la Ricerca’ (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia. Despite all this effectiveness, it has side effects that can be serious and bothersome. Sialorrhea is the most common adverse drug reaction that occurs during clozapine treatment. It is usually persistent, may impair the patient’s quality of life and reduce treatment compliance. However, there is limited evidence to guide possible treatment strategies for sialorrhea. N-Acetylcysteine (NAC) is a powerful antioxidant. It acts directly as a scavenger of free radicals, in particular oxygen radicals. The antiox...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Case Report Source Type: research
Authors: Shi LJ, Zhou HY, Wang Y, Shen YM, Fang YM, He YQ, Ou JJ, Li HB, Luo XR, Cheung EFC, Pantelis C, Chan RCK Abstract Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been reported in both individuals with schizophrenia and autism spectrum disorders (ASD). Despite overlaps, few studies have directly examined the neural mechanisms of impaired empathy in these two clinical groups. We used resting-state fMRI to investigate the neural correlates of empathic functioning in adolescents with ASD (N = 11), early-onset schizophrenia (EOS) (N = ...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Conditions:   Hyponatremia;   SIADH Intervention:   Other: Plasma sodium level (continuous variables) Sponsor:   Zealand University Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Ai Koizumi, Tomoki Hori, Brian Maniscalco, Makoto Hayase, Ryou Mishima, Takahiko Kawashima, Jun Miyata, Toshihiko Aso, Hakwan Lau, Hidehiko Takahashi, Kaoru Amano
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
For decades now, schizophrenia has been clearly understood as a disorder of neurodevelopment that is biologically manifest long before symptoms of frank psychosis. This realization led to efforts to understand the pathophysiological processes that precede psychosis, efforts which have lately come to fruition thanks to the study of the clinical high risk (CHR) state. CHR studies represent a unique opportunity for secondary prevention in psychiatry, i.e., an opportunity to intervene in the mechanisms that drive a disease process, thereby altering the course of illness and facilitating true recovery.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Psychiatric disorders, such as schizophrenia, depression, anxiety, and bipolar disorder, are common conditions that arise as a result of complex and heterogeneous combinations of genetic and environmental factors. In contrast to childhood neurodevelopmental conditions such as autism and intellectual disability, there are no clinical practice guidelines for applying genetic testing in the context of these conditions. But genetic counseling and genetic testing are not synonymous, and people who live with psychiatric disorders and their family members are often interested in what psychiatric genetic counseling can offer. Furt...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Genetic Counseling: Clinical Practice and Ethical Considerations PERSPECTIVES Source Type: research
The objective of this study was to further elucidate the role of ngn-1/neurogenin in nervous system development and to identify its downstream transcriptional targets, using the nematode Caenorhabditis elegans as a model for this work. We found that ngn-1 is required for axon outgrowth, nerve ring architecture, and neuronal cell fate specification. We also showed that ngn-1 may have roles in neuroblast migration and epithelial integrity during embryonic development. Using RNA sequencing and comparative transcriptome analysis, we identified eight transcription factors (hlh-34/NPAS1, unc-42/PROP1, ceh-17/PHOX2A, lim-4/LHX6, ...
Source: G3: Genes Genomes Genetics - Category: Genetics & Stem Cells Authors: Tags: Investigations Source Type: research
More News: Psychiatry | Schizophrenia