Customized FreeSurfer-based brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra tool

ConclusionsCustomized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Today I'll point out an example of drug reuse and autophagy upregulation. The processes of autophagy are responsible for recycling molecular waste and broken cellular structures. Autophagy is upregulated in response to stress placed upon cells, whether by heat, cold, lack of nutrients, a toxic local environment, and so forth. This is beneficial to tissue function, health, and longevity, and thus there is considerable interest in the research community in producing therapies that boost the operation of autophagy. This hasn't made a great deal of progress towards the clinic, but nonetheless in any of the sizable databases of...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Authors: Lyketsos CG Abstract Over 40 million people worldwide suffer from dementia. This number is projected to exceed 110 million by 2050 because of the aging of the worldwide population, especially in lower- and middle-income countries. The most common cause of dementia is believed to be Alzheimer's, a brain disease associated with deposition of beta-amyloid protein and hyperphosphorylation of intraneuronal tau protein leading to synaptic degradation, neuronal loss, brain circuit disruption, a range of symptoms, and eventually, if the person lives long enough, death. Over the last few decades, treatment developm...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractMultiple studies have investigated the disruptions in structural and functional connectivity in aging, dementia and Alzheimer ’s disease (AD). The study of metabolic connectivity between brain regions using fluorodeoxyglucose positron emission tomography (FDG-PET) however, is a new focus of interest. Several methodological approaches, including seed-based correlation, independent and principal component analysis, and gra ph-theoretical approaches have been employed to study the metabolic disconnectivity in AD. We conducted a systematic search of the literature using the keywords metabolic connectivity and Alz...
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Authors: Marinescu RV, Lorenzi M, Blumberg SB, Young AL, Planell-Morell P, Oxtoby NP, Eshaghi A, Yong KX, Crutch SJ, Golland P, Alexander DC Abstract We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only limited, unimodal data is available, by transferring information from larger multimodal datasets from common neurodegenerative diseases. DKT is a joint-disease generative model of biomarker progressions, which exploits bio...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
Conclusions: Although mGluR2 and mGluR5 have different synaptic location and functional mechanism both [11C]mG2P001 and [18F]FPEB showed significantly decreased radioactivity in their specific receptor binding regions in AD mice model compared to that of the control group. The MWM behavior test further indicated the reduced hippocampal radioactivity attributed to the observed cognitive/memory impairment among AD mice, where 19.3% and 34.3% radioactivity decrease were seen for [11C]mG2P001 and [18F]FPEB in hippocampus, respectively. In addition, the aberrant changes of [11C]mG2P001 in subiculum, where the first accumulation...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research
218Background: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD), with most developing clinical dementia by their late 60s. While Aβ pathology has been previously characterized in this population, its relationship with neurofibrillary tau is much less well understood. Objectives: The focus of this study is to determine the associations between global Aβ and regional tau in DS, as well as assess the differences in these biomarkers between cognitively stable adults with DS (CS) and cases of cognitive impairment (MCI/AD). Methods: A total of 140 adults with DS (age = 39.3 ± 8.4 ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research
Conclusions: This study shows that the PES of Aβ-ADCRP is a valid biomarker of underlying amyloid pathology, as demonstrated by its strong correlation with the Thal amyloid phase. The PES of FDG-ADCRP showed good correspondence with the Braak tangle stage and, therefore, the coherence between neurodegeneration and the distribution of tau pathology. References: 1. Blazhenets G, Ma Y, Sorensen A, et al. Principal Components Analysis of Brain Metabolism Predicts Development of Alzheimer Dementia. J Nucl Med. 2019;60:837-843. 2. Blazhenets G, Ma Y, Sorensen A, et al. Predictive Value of (18)F-Florbetapir and (18)F-FDG PET...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Amyloid & amp; Tau PET Source Type: research
Conclusion: The study demonstrates preliminary evidence of the potential beneficial impact of gamma-induction tACS protocols in AD, also showing the utility of Tau PET tracers as [18F]-AV-1451 for the reliable detection/quantification of modification in p-Tau deposition in AD. Acknowledgements: DARPA project D17AP00080, RO1A6060981, P41EB022544
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurodegenerative Diseases Source Type: research
Conclusions: For all four subjects in cognitive decline, [11C]UCB-J binding is reduced in the hippocampus when compared to the cognitively unimpaired A-/T- subjects. Decreased binding in the parahippocampus, inferior parietal lobe, medial frontal lobe, and/or the entorhinal cortex was also observed in some of those cases. Ongoing, longitudinal studies with larger sample sizes will investigate associations between cognitive, amyloid, and tau status with [11C]UCB-J measured synaptic density.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
Conclusion: Multimodality analyses using PiB-PET/MRI scans showed differences in regional CBF, cortical volume and neuronal networks in different regions, indicating that pathophysiologic and functional changes in the AD brain can be observed from various aspects of neurophysiologic parameters. Application of multimodal brain images would be ideal to investigate pathophysiologic changes in patients with dementia and other neurodegenerative diseases. References: Eur J Radiol 2018; 105: 102-109.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
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