Hepatitis B viruses in bats
Hepatitis B virus (HBV, illustrated) is a substantial human pathogen. WHO estimates that there are now 240,000,000 individuals chronically infected with HBV worldwide, of which 25% will die from chronic liver disease or hepatocellular carcinoma. The hepatitis B virus vaccine is highly effective at preventing infection. Because there are no known animal reservoirs of the virus, it is believed that HBV could be globally eradicated. The recent finding of HBV in bats raises the possibility of zoonotic introduction of the virus. Serum and liver samples from 3,080 bats from Panama, Brazil, Gabon, Ghana, Germany, Papua New Guinea, and Australia were screened for HBV-like sequences by polymerase chain reaction (PCR). Ten positive specimens were found from three bat species: Uroderma bilobatum from Panama, and Hipposideros cf. ruber and Rhinolophus alcyone from Gabon. The complete viral genome sequence was determined for 9 of the positive specimens. Phylogenetic analysis revealed that the bat viruses form three different lineages, and that each virus differs by at least 35% from known hepadnaviruses. The virus from Hipposideros cf. ruber has been named roundleaf bat HBV, while those from Rhinolophus and Uroderma have been named horshoe bat HBV, and tent-making bat HBV. Viral DNA in the liver of Hipposideros bats was found to be higher than in other organs or serum. Some lymphocyte infiltration was observed in the liver of these animals, as well as deposits of viral DNA within hepatocy...
Authors: Shi X, Zhou R, Zheng L, Jiang M Abstract Aim: The clinicopathological and prognostic significance of C-MYC dysregulation (amplification or overexpression) in esophageal squamous cell carcinoma (ESCC) remains controversial. Therefore, we performed this meta-analysis to elucidate this relationship. Materials &methods: Available studies were retrieved from PubMed, Web of Science, EMBASE and the Cochrane Library, and ten studies with a total of 1432 patients were included in this meta-analysis. Results: Pooled results showed that C-MYC dysregulation was significantly associated with poor overall ...
Publication date: Available online 28 May 2020Source: Veterinary MicrobiologyAuthor(s): Yuying Han, Libao Xie, Mengqi Yuan, Yuteng Ma, Huimin Sun, Yuan Sun, Yongfeng Li, Hua-Ji Qiu
Conclusions: We have completed a novel drug resistance screen in vivo, and identified that LXR agonism potentiates the efficacy of sorafenib in treating HCC.
Conclusiones. Este es el primer estudio que reporta variantes del gen LMP1-EBV en Cali, Colombia. Se requieren nuevos estudios para caracterizar la variante sin identificar y determinar si es patogénica o si es una variante geográfica presente exclusivamente en la ciudad. PMID: 32463610 [PubMed - as supplied by publisher]
[Prevalencia de leptospirosis en perros de trabajo vacunados y en población humana con riesgo ocupacional]. Biomedica. 2020 May 01;40(Supl. 1):62-75 Authors: Murcia CA, Astudillo M, Romero MH Abstract Introducción. Los perros de trabajo pueden infectarse con diversas serovariedades de Leptospira que se mantienen en sus túbulos renales e intersticios por mucho tiempo, por lo que se convierten en portadores y fuentes de infección para otros huéspedes. Objetivo. Establecer la prevalencia de Leptospira spp. en perros de trabajo vacunados y en población humana con r...
DISCUSSION: The SentiMag represents a fast and safe preoperative marking system of non-palpable breast lesions, cutting the radio exposure for personnel and patients. The marker is not displaced over time and it is rapid to place and easy to locate intraoperatively, allowing a clear dissection plane around the lesion. Thus, this reduces the amount of gland removed, improving the aesthetic result mostly in small breasts. PMID: 32456397 [PubMed - as supplied by publisher]
CONCLUSIONS: LH is a useful predictive tool in the evaluation of RLN LN metastasis for esophageal cancer. The present findings support the result that LH can be an indicator of RLN LN dissection. PMID: 32456390 [PubMed - as supplied by publisher]
Authors: Desilets A, Soulières D Abstract INTRODUCTION: Programmed death 1 (PD-1) blockade has changed the therapeutic landscape of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) with convincing overall response rates and overall survival benefits when compared to chemotherapy alone. The toxicity profile of pembrolizumab appears to be similar to that of other PD-1 or PD-L1 inhibitors, with frequent diarrhoea, hypothyroidism or cutaneous rash cases, and rare cases of grade 3 to 5 pneumonitis.Areas covered: In this article, the pharmacokinetics and mechanism of action of pembrolizuma...
The chief executive of AstraZeneca, which is developing a leading coronavirus vaccine with Oxford University, said it is too early to deliberately expose vaccine trial participants to the pathogen, but it may become an option if ongoing trials hit a snag.Reuters Health Information
Publication date: Available online 28 May 2020Source: Urology Case ReportsAuthor(s): Turki O. Al-Hussain, Bushra Alahmadi, Noor Nabi Junejo, Kawther Alshammari, Nasir Bakshi, Hassan Al Zaharni
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