Cell-free scaffold from jellyfish Cassiopea andromeda (Cnidaria; Scyphozoa) for skin tissue engineering

Publication date: June 2020Source: Materials Science and Engineering: C, Volume 111Author(s): Irving Fernández-Cervantes, Nayeli Rodríguez-Fuentes, Lorena V. León-Deniz, Luz E. Alcántara Quintana, José M. Cervantes-Uc, Wilberth A. Herrera Kao, José D. Cerón-Espinosa, Juan V. Cauich-Rodríguez, Victor M. Castaño-MenesesAbstractDisruption of the continuous cutaneous membrane in the integumentary system is considered a health problem of high cost for any nation. Several attempts have been made for developing skin substitutes in order to restore injured tissue including autologous implants and the use of scaffolds based on synthetic and natural materials.Current biomaterials used for skin tissue repair include several scaffold matrices types, synthetic or natural, absorbable, degradable or non-degradable polymers, porous or dense scaffolds, and cells capsulated in hydrogels or spheroids systems so forth. These materials have advantages and disadvantages and its use will depend on the desired application. Recently, marine organisms such as jellyfish have attracted renewed interest, because both its composition and structure resemble the architecture of human dermic tissue. In this context, the present study aims to generate scaffolds from Cassiopea andromeda (C. andromeda), with application in skin tissue engineering, using a decellularization process. The obtained scaffold was studied by infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), differential scannin...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research