An association between niacin skin flush response and plasma triglyceride levels in patients with schizophrenia

Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Sergej Nadalin, Suzana Jonovska, Vesna Šendula Jengić, Alena Buretić-TomljanovićABSTRACTThe available data suggest that abnormalities of arachidonic acid-related signaling may be of relevance in attenuated niacin-induced flush responses and lipid and glucose metabolism disturbances, which are all common among individuals with schizophrenia. We previously demonstrated attenuated skin flush responses to niacin in patients with schizophrenia. Here we investigated whether these niacin responses might be associated with elevated plasma lipid and glucose concentrations in this patient group. We found that higher plasma triglyceride levels were associated with higher total volumetric niacin response (VNR) values and that the VNR accounted for ∼14.2% of the variability in triglyceride levels. Triglyceride levels were significantly higher in patients with a positive niacin skin flush response compared to those with absent niacin skin flushing at the 5-minute interval with niacin concentrations of 0.1 and 0.01 M, and at the 10- and 15-minute intervals with a niacin concentration of 0.001 M.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research

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CONCLUSION: Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin. PMID: 32492767 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Authors: Pretus C, Bergé D, Guell X, Pérez V, Vilarroya Ó Abstract Negative symptoms in the motivational domain are strongly correlated with deficits in social and occupational functioning in schizophrenia. However, the neural substrates underlying these symptoms remain largely unknown. Twenty-eight adults with schizophrenia and twenty healthy volunteers underwent functional magnetic resonance while completing a lottery game designed to capture reward-related cognitive processes. Each trial demanded an initial investment of effort in form of key presses to increase the odds of winning. Brain ac...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
This study analyzes eight qualitative research studies published from 2000 to 2018 on the job experiences of people with schizophrenia to identify participants' job motivations, negative and positive experiences working with schizophrenia, and adaptations to gain social roles and values. We found that the core theme encompassing participants' experiences was the need for social support to facilitate reentry into society from the schizophrenic cave. These results could inform the development of targeted nursing interventions to provide social support and foster job adaptation for people with schizophrenia. PMID: 3249745...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
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Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
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Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Source Type: news
Condition:   Schizophrenia Intervention:   Combination Product: Risperidone Sponsors:   Delpor, Inc.;   National Institute of Mental Health (NIMH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Schizophrenia;   Schizoaffective Disorder;   Schizophreniform Disorders Interventions:   Device: Repetitive Transcranial Magnetic Stimulation;   Device: Repetitive Transcranial Magnetic Stimulation (Intermittent Theta Burst Stimulation);   Device: Repetitive Transcranial Magnetic Stimulation (Sham) Sponsors:   Centre for Addiction and Mental Health;   The Feinstein Institute for Medical Research;   Maryland Psychiatric Research Centre;   National Institutes of Health ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
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Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
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Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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