Maternal dietary fatty acids and their roles in human placental development

Publication date: Available online 21 February 2020Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): Asim K. Duttaroy, Sanjay BasakAbstractFatty acids are essential for feto-placental growth and development. Maternal fatty acids and their metabolites are involved in every stage of pregnancy by supporting cell growth and development, cell signaling, and modulating other critical aspects of structural and functional processes. Early placentation process is critical for placental growth and function. Several fatty acids modulate angiogenesis as observed by increased tube formation and secretion of angiogenic growth factors in first-trimester human placental trophoblasts. Long-chain fatty acids stimulate angiogenesis in these cells via vascular endothelium growth factor (VEGF), angiopoietin-like protein 4 (ANGPTL4), fatty acid-binding proteins (FABPs), or eicosanoids. Inadequate placental angiogenesis and trophoblast invasion of the maternal decidua and uterine spiral arterioles leads to structural and functional deficiency of placenta, which contributes to preeclampsia, pre-term intrauterine growth restriction, and spontaneous abortion and also affects overall fetal growth and development. During the third trimester of pregnancy, placental preferential transport of maternal plasma long-chain polyunsaturated fatty acids is of critical importance for fetal growth and development. Fatty acids cross the placental mi...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research

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This study was conducted with the aim to assess obesity-related adverse maternal, neonatal and perinatal outcomes using new Asian Indian guidelines.MethodologyPregnant women up to 16-week gestation on first visit were enrolled. There were two exposure groups: one with BMI  
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
CONCLUSIONS: Our updated review suggests that metformin may be beneficial over placebo for live birth however, more women probably experience gastrointestinal side effects. We are uncertain if metformin plus CC improves live birth rates compared to CC alone, but gastrointestinal side effects are probably increased with combined therapy. When metformin was compared with CC, data for live birth were inconclusive, and the findings were limited by lack of evidence. Results differed by body mass index (BMI), emphasising the importance of stratifying results by BMI. No studies reported gastrointestinal side effects in this compa...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Discussion relating to one of these at least in the Guardian,Record number of over-45s giving birth in England, NICESurveillance report NICE guideline (NG126)Ectopic pregnancy and miscarriage: diagnosis and initial managementThis guideline will be updated:read this page to find out why.In the newsSinging the blues: how music can help ease postnatal depressionMelodies for Mums, an iniative that is part of a study being funded by the Wellcome.Maternity care failings in Shropshire (BMJ)OpinionBMJ editorialScreening for cytomegalovirus in pregnancy
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
ConclusionObesity is closely associated with primary infertility and PCOD. Menstrual abnormalities associated with PCOD significantly improve after bariatric surgery with significant improvement in fertility along with maternal outcomes.
Source: Obesity Surgery - Category: Surgery Source Type: research
Purpose of review In recent years, new studies have investigated the role and influence of sleep on female fertility and early pregnancy outcomes, providing a growing body of knowledge demonstrating how regulation by sleep of hormones are important to reproduction, and how disruptions in sleep, circadian rhythms, and genes regulating circadian rhythmicity can negatively impact fertility and early pregnancy outcomes. This review aims to summarize the most recent research on the relationship among circadian rhythms, fertility, and early pregnancy outcomes in women, and to explore possible fertility interventions. Recent f...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: REPRODUCTIVE ENDOCRINOLOGY: Edited by Wendy Kuohung Source Type: research
Obesity has a major impact on the health of women at reproductive age and during pregnancy [1,2]. Obesity has several deleterious effects on female reproductive function, which includes obesity-associated hypothalamic-gonadal dysfunction, fertility impairment, and increased rate of miscarriages [3]. Women with obesity also incur in higher risks of pregnancy-related mortality and morbidity, because the prevalence of gestational diabetes, fetal growth restriction, prematurity, stillbirth, traumatic delivery, and some congenital malformations are increased [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Editorial comment Source Type: research
Obesity has a major impact on the health of women at reproductive age and during pregnancy [1,2]. Obesity has several deleterious effects on female reproductive function, which includes obesity-associated hypothalamic-gonadal dysfunction, fertility impairment, and increased rate of miscarriages [3]. Women with obesity also incur in higher risks of pregnancy-related mortality and morbidity, because the prevalence of gestational diabetes, fetal growth restriction, prematurity, stillbirth, traumatic delivery, and some congenital malformations are increased [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Editorial comment Source Type: research
Obesity has a major impact on the health of women at reproductive age and during pregnancy [1, 2]. Obesity has several deleterious effects on female reproductive function, which includes obesity associated hypothalamic-gonadal dysfunction, fertility impairment and increased rate of miscarriages [3]. Women with obesity also incur in higher risks of pregnancy related mortality and morbidity, since the prevalence of gestational diabetes, fetal growth restriction, prematurity, stillbirth, traumatic delivery and some congenital malformations is increased [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
AbstractBackgroundGestational diabetes mellitus (GDM) is a major public health problem and threat to maternal and child health in Africa. No prior review has been conducted in Africa using the updated GDM diagnostic criteria. Therefore, this review aimed to estimate the pooled prevalence and determinants of GDM in Africa by using current international diagnostic criteria.MethodsA systematic review and meta-analysis was conducted by comprehensive search of the published studies in Africa. Electronic databases (PubMed, Scopus, Cochrane Library, EMBASE, Google Scholar, CINAHL, Web of Science, Science direct and African Journa...
Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
PREGNANCY OUTCOME IN GESTATIONAL DIABETES COMPARED TO BODY MASS INDEX. Acta Clin Croat. 2019 Mar;58(1):37-41 Authors: Sabolović Rudman S, Djaković I, Gall V, Djaković Ž, Košec V Abstract Gestational diabetes involves disorder of glucose metabolism first diagnosed in pregnancy. Obese women undoubtedly have more often complications in reproductive age, such as fertility difficulties, spontaneous and recurrent miscarriages, premature births, and various obstetric and surgical complications related to the course of pregnancy, delivery and puerperium. Children of obese pregnant women are more lik...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
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