An association between niacin skin flush response and plasma triglyceride levels in patients with schizophrenia
Phospholipase A2 (PLA2) activation triggers the release of arachidonic acid (20:4n-6, ARA) from membrane phospholipids, and this mechanism is reportedly involved in a variety of physiological processes, including dopaminergic neurotransmission, insulin secretion and the skin flush response to the water-soluble B vitamin niacin [1-6]. Individuals with schizophrenia frequently exhibit abnormal signaling of dopamine and other neurotransmitters, disturbances of lipid and glucose metabolism and attenuated niacin-induced skin flushing [1,4,5,7-9].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Sergej Nadalin, Suzana Jonovska, Vesna Šendula Jengić, Alena Buretić-Tomljanović Tags: Original research article Source Type: research
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