Substantial tumor regression in prostate cancer patient with extensive skeletal metastases upon Immunotherapy (APCEDEN): A case report

This study presents a case of prostate carcinoma and the tumour remission observed after administration of a personalised Dendritic cell vaccine (APCEDEN). Patient concerns: A 58 years old Caucasian male diagnosed with prostate carcinoma with GLEASON score 8. The patient had previously been diagnosed with Renal Cell Carcinoma (RCC) in 1996 and had undergone nephrectomy of the right kidney. PET CT scan revealed multiple intensely PSMA avid lesions noted in both lobes of the prostate gland with SUVmax −28.3 and the prostate gland measuring 3.2 × 3.2 cm displaying maximum dimensions. Diagnosis: FNAC followed by PETCT confirmed CA Prostate and further supported by increased serum PSA level. Interventions: The patient underwent personalised Dendritic Cell Immunotherapy APCEDEN regimen of six doses biweekly, in a time frame of 3 months were given both via intravenous and intradermal route. Six months post completion of APCEDEN, the patient was administered 6 booster shots for 6 months. Outcomes: Progressive remission of carcinoma was observed along with reduction in PSA and Testosterone levels. PET CT showed decline in PSMA avidity by 50% with SUVmax −14.0 and normal size and shape of prostate gland. Lessons: Prostate carcinoma is the second most common cancer in men with majority of them exhibiting locally advanced disease. Apparently 20% to 30% of them are categorized as relapsed cases after various therapeutic interventions. Modulating immu...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Related Links:

Publication date: Available online 30 May 2020Source: Pathology - Research and PracticeAuthor(s): Wenjing Qi, Chang Shi, Pengxin Zhang, Lu Feng, Junying Wang, Dan Chen
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 30 May 2020Source: Gynecologic Oncology ReportsAuthor(s): Anya Laibangyang, Raanan Alter, Yasmin Hasan, S. Diane Yamada
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 30 May 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Hai Xu, Yale Niu, Weiming Hong, Weixin Liu, Xiaoxin Zuo, Xi Bao, Changming Guo, Yu Lu, Bihua Deng
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 30 May 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Ahmad Erfanmanesh, Arash Ghalyanchilangeroudi, Donya Nikaein, Hossein Hosseini, Tahereh Mohajerfar
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 30 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Kevin C. Lee, Sung-Kiang Chuang
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 30 May 2020Source: Pharmacological ResearchAuthor(s): Ling Wang, Ke Deng, Liang Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zijie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song, Desheng Lu
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Jie Yu, Bingling Zhong, Qingwen Xiao, Lida Du, Ying Hou, Hong-Shuo Sun, Jin-Jian Lu, Xiuping Chen
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Kevin M. Levine, Kai Ding, Lyuqin Chen, Steffi Oesterreich
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qi Chen, Huachao Xu, Jiang Zhu, Kehai Feng, Changlu Hu
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Celso Alves, Eurico Serrano, Joana Silva, Carlos Rodrigues, Susete Pinteus, Helena Gaspar, Luis M. Botana, Maria C. Alpoim, Rui Pedrosa
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Colorectal Cancer | CT Scan | Fine Needle Aspiration | Immunotherapy | Internal Medicine | Kidney Cancer | Lessons | Nephrectomy | PET Scan | Prostate Cancer | Renal Cell Carcinoma | Study | Urology & Nephrology | Vaccines