Microvascular Phenotyping in The Maastricht Study: Design, and Main findings, 2010-2018.

Microvascular Phenotyping in The Maastricht Study: Design, and Main findings, 2010-2018. Am J Epidemiol. 2020 Feb 20;: Authors: Li W, Schram MT, Sörensen BM, Agtmaal MJM, Berendschot TTJM, Webers CAB, Jansen JFA, Backes WH, Gronenschild EHBM, Schalkwijk CG, Stehouwer CDA, Houben AJHM Abstract Microvascular dysfunction (MVD) is a common pathophysiological change in various diseases, such as type 2 diabetes mellitus (T2DM), heart failure, dementia and depression. Recent technical advances enable the measurement and quantification of microvascular changes non-invasively in humans. In this paper, we describe the protocols of the microvascular measurements applied in The Maastricht Study, an ongoing prospective population-based cohort study, which includes a variety of non-invasive measurements in skin, retina, brain, and sublingual tissue as well as plasma and urine biomarker assessments. Following this, we summarize our main findings involving these microvascular measurements up to 2018. Finally, we provide a brief perspective of future microvascular investigations, within the framework of The Maastricht Study. PMID: 32077474 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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