Researchers identify novel potential combination therapy for childhood brain tumors

(Write Science Right) Brazilian researchers working in collaboration with Canadian scientists demonstrated that all medulloblastoma tumor subtypes express two stem cell markers: BMI1 and CD133. When they induced DNA chromatin relaxation, tumor cell viability was reduced with down-regulation of BMI1 and CD133. These anti-tumor effects could be potentiated by concurrent inhibition of MAPK/ERK signaling.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news