Weakly coordinating group directed rhodium-catalyzed unconventional site-selective C-H olefination of indolizines at the 8-position

Publication date: Available online 20 February 2020Source: Chinese Chemical LettersAuthor(s): Xue Feng, Jiaxin Tian, Ying Sun, Huayou Hu, Mingzhu Lu, Yuhe Kan, Danjun Fang, Chao WangAbstractA rhodium-catalyzed directing group promoted selective C–H olefination reaction of indolizines at the 8-position is reported. Di-olefination at 2,8-positions also achieved with silver hexafluoroantimonate as an additive under similar reaction conditions. Weakly coordinating groups, such as ketone, aldehyde, amide and ester, were used as directing groups. The ester group can be removed under acid conditions and therefore is used as a traceless directing group.Graphical AbstractA rhodium-catalyzed directing group promoted selective C–H olefination reaction of indolizines at the 8-position is reported. Weakly coordinating groups, such as ketone, aldehyde, amide and ester, were used as directing groups. The ester group can be removed under acid conditions and therefore is used as a traceless directing group.

Source: Chinese Chemical Letters - February 21, 2020 Category: Chemistry Source Type: research