GIP and GLP-1 Receptor Antagonism During a Meal in Healthy Individuals.

CONCLUSIONS: Endogenous GIP and GLP-1 lower postprandial plasma glucose excursions and stimulate insulin secretion but only endogenous GIP affects gallbladder motility. The two incretin hormones potentiate each other's effects in the control of postprandial glycemia in healthy men.
PMID: 32077470 [PubMed - in process]

Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2020 Category: Endocrinology Authors: Gasbjerg LS, Helsted MM, Hartmann B, Sparre-Ulrich AH, Veedfald S, Stensen S, Lanng AR, Bergmann NC, Christensen MB, Vilsbøll T, Holst JJ, Rosenkilde MM, Knop FK Tags: J Clin Endocrinol Metab Source Type: research