Lipid signaling from beta cells can potentiate an inflammatory macrophage polarization

(University of Alabama at Birmingham) The insulin-producing beta cells in the pancreas unwittingly produce a signal that may aid their own demise in Type 1 diabetes, according to a study of the lipid signals that drive macrophage cells in the body to two different phenotypes of activated immune cells.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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In conclusion, our case-control and meta-analysis studies did not indicate an association between the analyzed UCP2 polymorphisms and DKD.
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Authors: Urakami T Abstract For the increasing number of type 1 diabetes in Japan, after 1960, a greater supply of insulin was required, accordingly the availability of insulin gradually improved, The National Health Insurance approved self-injections of insulin at home in 1981. Afterwards, intensive insulin treatment with short-acting insulin and intermediate-acting insulin became widely used. Recombinant rapid-acting insulin analog was introduced in 1986 and long-acting insulin analog was introduced in 2003. In recent years, basal-bolus insulin regimens using these insulin analogs have become popular in children ...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Marque NA, Lazo-Porras M, Schwitzgebel V, Castellsague M, Cimarelli G, Dirlewanger M, Klee P, Perrenoud L, Beran D Abstract Globally it is estimated that over 1 million children and adolescents have Type 1 diabetes with large variations in incidence between different contexts. Health systems need to provide a variety of elements to ensure appropriate diabetes care, such as service delivery; healthcare workforce; information; medical products and technologies; financing and leadership and governance. Describing these elements between Geneva, Switzerland, a high-income country with high spending on healthcar...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Tuomilehto J, Ogle GD, Lund-Blix NA, Stene LC Abstract Epidemiological data on pediatric type 1 diabetes (T1D), mainly incidence, have become increasingly available since the second half of the 20th century. Comparative incidence data across populations were only obtained since the 1980s. The 2019 IDF Atlas provides T1D incidence, prevalence and mortality estimates for children
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Ludvigsson J Abstract The negative consequencies of diabetes treatment are traditionally regarded as caused by a disastrous treatment rather than adverse events of the insulin preparations. However, hypoglycemia, changes at the injection site (lipatrophy, lipoma), insulin allergy, obesity and increased risk of certain forms of cancer can easily be regarded as adverse events of the drug, and needle-phobia, psychological problems, increased risk of suicide are adverse events related to insulin and its administration. Also macroangiopathy and even microangiopathy to some extent can be regarded as adverse even...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Nimri R Abstract For people with type 1 diabetes, achieving optimal glycemic control requires use of intensive insulin therapy. To achieve this goal individuals are required to become proficient in accurately determining the appropriate amount of insulin needed to address a variety of situations throughout the day while considering numerous influencing factors. They also need to perform multiple tasks a day such as counting carbohydrates to accurately determine the required premeal bolus. There is also a need to periodically adjust insulin dosing as insulin sensitivity varies considerably over time. Sophis...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Zimmerman C, Forlenza G, Schatz D Abstract The isolation and purification of insulin nearly 100 years ago has been one of the most ground-breaking discoveries in the history of medicine. Subsequent determination of the specific structure of human insulin has permitted further developments and modifications of the formulations of insulin to allow improved quality of care and quality of life for patients with diabetes. In this paper, we will review insulin structure and biosynthesis, treatment and prognosis of type 1 diabetes prior to insulin therapy, experimentation leading to the discovery of insulin, and ...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Reassuringly, COVID-19 in under 25s with diabetes doesn't seem to require hospitalization, early reports from global hotspots indicate. But the pandemic means new cases of type 1 diabetes are being missed.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news
Managing insulin-dependent diabetes is no easy task. Most patients manually measure blood glucose and calculate insulin dosing using traditional multiple dose injection (MDI) therapy, a burdensome process that puts them at risk for both hypo- and hyp...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Source Type: blogs
CONCLUSIONS: PPE was found to have a moderate therapeutic effect against a hepatic alteration in the male rats. It could be advised for diabetic patients suffering from the early alteration of liver functions. PMID: 32207851 [PubMed - as supplied by publisher]
Source: Folia Morphologica - Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research
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