Predicting Early Post-stroke Aphasia Outcome From Initial Aphasia Severity

Background: The greatest degree of language recovery in post-stroke aphasia takes place within the first weeks. Aphasia severity and lesion measures have been shown to be good predictors of long-term outcomes. However, little is known about their implications in early spontaneous recovery. The present study sought to determine which factors better predict early language outcomes in individuals with post-stroke aphasia.Methods: Twenty individuals with post-stroke aphasia were assessed
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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CONCLUSION: In summary, the method applied to nCT scans performed in the acute stage of stroke provided robust and accurate information about brain lesions' location and size, as well as quantitative values. We found that nCT and VBQ analyses areeffective for identifying neural signatures of concomitant language impairments at the individual level, and neuroanatomical maps of aphasia at the population level. The signatures explicate the neurophysiological mechanisms underlying aetiology of the stroke. Ultimately, similar analyses with larger cohorts could lead to a more integrated multimodal model of behavior and brain ana...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
One ‐third of patients with ischaemic stroke before 70 years of age showed increased muscle tone at 7‐year follow‐up. Half of them also had classical spasticity, and almost every tenth had one or more contractures. Increased muscle tone was predicted by age, arm paresis, aphasia, and facial palsy at index stroke. AbstractBackgroundSystematic studies on increased muscle tone and spasticity late after ischemic stroke, without any selection, are limited. Therefore, we aimed to determine the prevalence of increased muscle tone, classical spasticity and contracture and predictors of increased muscle tone seven years after...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Can you distinguish the taste of a red wine versus a rosé? How about the look of a 1960s muscle car versus a foreign import? Do you prefer to grow lilies or tulips? Would you rather listen to Dark Side of the Moon or “Fly Me to the Moon”? To answer any of these questions, you need to use your semantic memory. Your semantic memory is your store of factual knowledge of the world and the meaning of words. It’s how you know that a fork is for eating (not twirling your hair) and what color a lion is. It’s both the source of your vocabulary and how you know what something does even if you don&rsquo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Healthy Aging Memory Source Type: blogs
Abstract Purpose The brain-derived neurotrophic factor (BDNF) gene has been shown to be important for synaptic plasticity in animal models. Human research has suggested that BDNF genotype may influence stroke recovery. Some studies have suggested a genotype-specific motor-related brain activation in stroke recovery. However, recovery from aphasia in relation to BDNF genotype and language-related brain activation has received limited attention. We aimed to explore functional brain activation by BDNF genotype in individuals with chronic aphasia. Consistent with findings in healthy individuals and individuals with po...
Source: Journal of speech, language, and hearing research : JSLHR - Category: Speech-Language Pathology Authors: Tags: J Speech Lang Hear Res Source Type: research
DiscussionThe aim of this study is to assess the efficacy of tDCS for language/semantic disorders in semantic dementia. A potential treatment would be easily applicable, inexpensive, and renewable when therapeutic effects disappear due to disease progression.Trial registrationClinicalTrials.govNCT03481933. Registered on March 2018.
Source: Trials - Category: Research Source Type: clinical trials
In conclusion, FAS is a rare motor speech disorder, often related to cerebrovascular accidents involving critical regions in the dominant hemisphere. In addition, the present case adds further evidence to the role of the left primary motor cortex in modulation of prosody. In rare cases FAS can be the only sign of stroke or can appear after recovery from post-stroke aphasia.
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: Available online 14 October 2019Source: NeuroImage: ClinicalAuthor(s): Robert Loughnan, Diego L. Lorca-Puls, Andrea Gajardo-Vidal, Valeria Espejo-Videla, Céline R. Gillebert, Dante Mantini, Cathy J. Price, Thomas M.H. HopeAbstractAround a third of stroke survivors suffer from acquired language disorders (aphasia), but current medicine cannot predict whether or when they might recover. Prognostic research in this area increasingly draws on datasets associating structural brain imaging data with outcome scores for ever-larger samples of stroke patients. The aim is to learn brain-behavior trends from ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The NEURAL (NEURoscience of Adult Language) Research Lab at Indiana University Bloomington is seeking a postdoctoral fellow to begin in spring or summer 2020, working with Dr. Brielle Stark. The position is open for an initial 1-year, with an option to renew dependent on performance and funding.Research in the lab focuses on understanding brain-behavior relationships in neurogenic communication disorders, largely post-stroke aphasia. We are most interested in understanding processes related to language production. We have a Siemens Prisma 3T MRI scanner and an EEG suite as part of our Imaging Research Facility, which ...
Source: Talking Brains - Category: Neuroscience Authors: Source Type: blogs
Photo provided by Avi Golden Avi Golden is an EMT who can no longer talk after suffering a stroke. He now makes it his mission to educate others about those dealing with aphasia.   Editor’s Introduction It was a chance encounter one day as I scanned Facebook posts from “friends” and acquaintances. I have countless “friends”, many of which I have never met in person, but find, through their content or other “friends” to be in my world of interest and specialization. Several postings were from paramedic Avi Golden, one such “friend” I followed frequently on Facebook ...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Training Exclusive Articles Patient Care Source Type: news
The relationship between the left arcuate fasciculus (AF) and stroke-related aphasia is unclear. In this retrospective study, we aimed to investigate the role of subcomponents of the left AF in predicting prognosis of aphasia after stroke. Twenty stroke patients with aphasia were recruited and received language assessment as well as diffusion tensor tractography scanning at admission. According to injury of the left AF, the participants were classified into four groups: group A (4 cases), the AF preserved intactly; group B (6 cases), the anterior segment injured; group C (4 cases), the posterior segment injured; and group ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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