Parkinson ’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson ’s disease (PD), the most common age-related movement disorder. The dysfunction of ...

Source: Molecular Neurodegeneration - February 19, 2020 Category: Neurology Authors: Xi Chen, Chengsong Xie, Wotu Tian, Lixin Sun, Zheng Wang, Sarah Hawes, Lisa Chang, Justin Kung, Jinhui Ding, Shengdi Chen, Weidong Le and Huaibin Cai Tags: Research article Source Type: research