Congratulations to our latest Early Career Grant awardees

Congratulations to our Early Career Members awarded Early Career Grants of up to£10,000 to help fund their endocrine research.Alisdair Boag (Roslin Institute) - Delineating the consequences of thiosulfate sulfurtransferase (TST) overexpression in EndoCbH1 cellsNeil Martin (Loughborough University) - Investigating the lysosomal metabolome and mTORC1 localisation in aged human skeletal muscleMorag Mansley (University of Edinburgh) - Functional characterisation of novel corticosteroid-induced transcripts in the cortical collecting ductAndrea Pollard ‚Äč (Imperial College London) - Identification of a novel regulator of osteoblast functionAntonia Solomou (Kings College London) - Understanding how genetics and maternal obesity interact to determine adipocyte progenitor cell behaviourSophie Clarke (Imperial College London) - Using Kisspeptin to improve in vitro oocyte maturationBenjamin Flynn (University of Bristol) - Recapitulation of ultradian glucocorticoid oscillations is important for homeostatic metabolic controlCarl Jenkinson (University of Birmingham) - Investigating vitamin D and steroid hormone metabolism in postmenopausal osteoporosisAnne van der Spek (Academic Medical Centre) - Macrophage differentiation and function in patients with Resistance to Thyroid HormoneEarly Career Members can apply for Society Early Career Grants to help fund research or gather preliminary data to apply for other external fundi...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: Obesity and mild unmedicated metabolic risk factors alter the circulating steroid profile and bias the estimation of reference limits for testosterone, dihydrotestosterone, cortisol and corticosterone. Applying age-dependent reference intervals is mandatory for steroid precursors and corticosteroids. PMID: 32130202 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
ConclusionsSpecialist-diagnosed CC was associated with considerable disease burden, particularly among those with both respiratory disease and GERD. Additionally, CC burden was more pronounced than in matched non-cough patients.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusion: Vasopressin should remain second-line adjunct to norepinephrine to augment mean arterial pressures. Dosing should be initiated at 0.03 U/min, and higher doses offer minimal benefit. There are conflicting data on the impact of weight on vasopressin response. Studies have failed to show renal benefit with vasopressin use or an interaction with corticosteroid therapy. PMID: 31958982 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - Category: Drugs & Pharmacology Authors: Tags: Ann Pharmacother Source Type: research
Abstract BACKGROUND: The long-term clinical course of asthma in patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA) remains unclear. We aimed to characterize long-term asthma in EGPA and to identify baseline predictors of long-term asthma severity. METHODS: Retrospective cohort study of patients who fulfilled standardized criteria for EGPA that were followed in a single referral center between 1990-2017. Baseline and 3 (±1) years of follow-up clinical, laboratory and pulmonary function data were analyzed. RESULTS: Eighty-nine patients with EGPA, and a documented asthma assessment at...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Spinal epidural lipomatosis (SEL) is a rare condition defined as pathological overgrowth of the normally present epidural fat within spinal canal. SEL is associated with Cushing disease, obesity and chronic corticosteroid therapy. Diabetes mellitus type 1 (DM1) has not known to be a risk factor for SEL. The neurological symptoms of SEL are attributed mainly to mechanical compression on the spinal cord and the cauda equina.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Clinical Short Communication Source Type: research
Authors: Hernigou P, Gerber D, Auregan JC Abstract BACKGROUND: The knee is the second-most common location for osteonecrosis, although it is affected much less often than the hip. Core decompression by precise drilling into ischemic lesions of the femoral condyle while remaining extra-articular is a challenge, particularly in obese patients. For cell therapy, exact localization of the injection point is important to avoid intra-articular injection. METHODS: The precision of drilling with computer-based navigation was compared to that of conventional fluoroscopy-based drilling. A prospective, randomized study wa...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
CONCLUSIONS: Specific signs and symptoms, chronic conditions, a greater comorbidity burden, and specific pharmacological treatments registered in primary care databases represent relevant predictors and correlates of incident IDA in older people in Europe. General practitioners might employ this information to obtain early diagnosis of IDA in community-dwelling older adults. PMID: 31893385 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
Publication date: January–February 2020Source: The Journal of Foot and Ankle Surgery, Volume 59, Issue 1Author(s): Ali Tabrizi, Sina Dindarian, Sedra MohammadiAbstractChronic plantar heel pain (CPHP) is one of the most common painful and disabling foot conditions, for which various treatments have been proposed. We aimed to investigate the efficacy of local injection of platelet-rich plasma (PRP) compared with the conventional method of local corticosteroid injection in obese patients who were resistant to other nonsurgical treatments. In this single-blind, randomized clinical trial, 32 obese patients with chronic pl...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Background: There is little information on the state of asthma, particularly severe asthma, in China.Objectives: To determine the characteristics of severe asthma patients in China and their stability.Methods: We recruited adults with severe asthma (n=349 non-smokers, NSA, &n=114 smokers and ex-smokers, SSA), mild/moderate asthma (MMA; n=97) and healthy controls (HS, n=100) from 33 university hospitals in 15 provinces. Severe asthma was defined by 2014 ERS/ATS guidelines.Results: NSA was mostly female (70%) but SSA exclusively (96.5%), with both groups having most obese subjects (BMI>28) (NSA: 14.6% and SSA: 17.5% v...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
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