Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: Contemporaneous Portuguese cross-sectional data

ConclusionsIn 2016, according to data from these national registries, almost all patients with STEMI were treated with aspirin and 76% with dual antiplatelet agents, mostly clopidogrel. GP IIb/IIIa inhibitors were used in few patients, and UFH was the most prevalent parenteral anticoagulant drug.ResumoIntroduçãoO tratamento do enfarte agudo do miocárdio com elevação do segment ST (EAMCSST) baseia-se na ativação da via verde coronária, na administração de terapêutica médica adjuvante e na reperfusão através de angioplastia primária percutânea. A angioplastia primária constitui o tratamento de primeira linha para o EAMCSST e a terapêutica antitrombótica, incluindo antiagregantes e anticoagulantes, a base do tratamento farmacológico, contribuindo para a melhoria do prognóstico.ObjetivoDescrever dados contemporâneos da vida real da utilização de terapêutica antitrombótica em Portugal, em doentes com EAMCSST submetidos a angioplastia primária.MétodosFoi realizado um estudo observacional retrospetivo baseado nos dados de dois registos nacionais referentes ao ano de 2016: o Registo Nacional de Síndromes Coronárias Agudas (RNSCA) e o Registo Português de Cardiologia de Intervenção (RPCI). Foram colhidos dados relativos à utilização de antiagr...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research

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(American College of Cardiology) An international clinical trial that used genetic testing to guide which antiplatelet medication was given to patients following percutaneous coronary intervention (PCI) did not meet its stated goal for cutting in half the incidence of serious adverse cardiovascular events, such as heart attack and stroke, in the year following the procedure, according to study results presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Authors: Aung AT, Chan SP, Kyaing TT, Lee CH Abstract Introduction: Compared to clinic blood pressure (BP), sleep-time BP and non-dipping BP pattern are better predictors of target organ damage and cardiovascular sequalae.Aim: In a retrospective study, we determined whether diabetes mellitus (DM) status is associated with high sleep-time BP and non-dipping pattern.Methods: We analyzed 1092 patients who underwent ambulatory BP monitoring between 2015 and 2017 in a tertiary cardiology institution. During a 24-hour period, BP was automatically measured every 15 minutes between 7:00 AM and 11:59 PM and every 30&nb...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Monocyte to High Density Lipoprotein Ratio (MHR) is a new marker that has been associated with major adverse cardiovascular outcomes among STEMI patients. We sought to strengthen the association between MHR an...
Source: Lipids in Health and Disease - Category: Lipidology Authors: Tags: Research Source Type: research
This study retrospectively enrolled 229 consecutive patients who had pPCI for acute STEMI within 2–7 days of symptom onset between January 2008 and December 2018. Patients were divided into no-reflow group (TIMI flow grade 0–2) and reflow group (TIMI flow grade 3). Predict ors of no-reflow were assessed by univariate and multivariate binary logistic regression analyses. Plasma D-dimer level can independently predict no-reflow in patients with STEMI who had pPCI within 2–7 days of symptom onset (OR 2.52 per 1 mg/L increase, 95% CI 1.16–5.47,p = 0.019). This finding indica...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
CONCLUSION: In patients with pPCI treated STEMI, suPAR was an independent prognostic biomarker of non-cardiac but not cardiac mortality and may identify patients with high risk of non-cardiac mortality. PMID: 32213303 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - Category: Biochemistry Authors: Tags: Clin Biochem Source Type: research
Publication date: Available online 19 March 2020Source: American Heart JournalAuthor(s): Mohammed Osman, Maryam Saleem, Khansa Osman, Babikir Kheiri, Sean Regner, Qais Radaideh, Jason A. Moreland, Sunil V Rao, Samir Kapadia
Source: American Heart Journal - Category: Cardiology Source Type: research
Out-of-hospital cardiac arrest (OHCA) is frequently associated with ST-elevation myocardial infarction (STEMI) and has a high mortality. We aimed to identify differences in characteristics and very long-term outcomes for STEMI patients with and without OHCA managed with percutaneous coronary intervention (PCI).
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Clinical paper Source Type: research
This study was designed as a multicenter, double-blind, randomized, placebo-controlled, parallel-group, superiority trial. Participants were randomly assigned in a 1:1 ratio through a centrally controlled, computer-generated, simple randomization schedule. The primary outcome was left ventricular end-diastolic volume index  = left ventricular end-diastolic volume/body surface area. The combined secondary outcomes include traditional Chinese medicine syndrome score, echocardiogram results, 6-minute walk test results, Seattle Angina Questionnaire score, cardiac magnetic resonance imaging results, biological ind...
Source: Trials - Category: Research Source Type: clinical trials
Abstract BACKGROUND: Prompt and potent antiplatelet effects are important aspects of management of ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI). We evaluated the association between platelet-derived thrombogenicity during PPCI and enzymatic infarct size in STEMI patients.Methods and Results:Platelet-derived thrombogenicity was assessed in 127 STEMI patients undergoing PPCI by: (1) the area under the flow-pressure curve for the PL-chip (PL18-AUC10) using the total thrombus-formation analysis system (T-TAS); and (2) P2Y12reaction units (PRU) usi...
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
AbstractAimsUrgent revascularization is the mainstay of treatment in acute coronary syndrome (ACS) related cardiogenic shock (CS). The aim was to investigate the association of angiographic results with 90 ‐day mortality. Procedural complications of percutaneous coronary intervention (PCI) were also examined.Methods and resultsThis CardShock (NCT01374867) substudy included 158 patients with ACS aetiology and data on coronary angiography and complications during PCI procedure. Survival analysis was conducted with Kaplan –Meier curves and Cox regression analysis. Median age was 67 ± 11 years, and 77% were men....
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Short Communication Source Type: research
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