Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe −/− Mice

ConclusionsSelective JAK2 inhibition reduces atherogenesis by suppressing excessive myelopoiesis in hypercholesterolemicApoe−/− mice. These findings suggest selective JAK2 inhibition as a potential therapeutic approach to decrease ACD risk in patients with increased myelopoiesis and leukocytosis.

Source: Cardiovascular Drugs and Therapy - February 20, 2020 Category: Cardiology Source Type: research