Protein tyrosine phosphatase 1B inhibitory triterpene glycosides from Mussaenda pilosissima Valeton

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Vu Kim Thu, Nguyen Xuan Bach, Nguyen Thi Thu Hien, Hua Thi Son, Tran Hong Quang, Youn-Chul Kim, Hyuncheol Oh, Phan Van KiemAbstractThree new triterpene glycosides, mussapilosides A–C (1-3) together with six known triterpene glycosides, cincholic acid-28-O-β-d-glucopyranosyl ester (4), mussaendoside S (5), quinovic acid 28-O-β-d-glucopyranosyl ester (6), glycoside A (7), glycoside B (8), and quinovic acid 3-O-β-d-glucopyranosyl(1→2)-β-d-glucopyranoside (9) were isolated from the leaves of Mussaenda pilosissima. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, and HR ESI MS spectra. All these compounds were examined for their inhibitory activity against PTP1B. The results indicated that compounds 2, 6, and 8 exhibited potent inhibitory effects with IC50 values of 3.4 ± 0.2, 4.2 ± 0.2, and 6.4 ± 0.2 μM, respectively. Compound 5 showed the moderate inhibitory effect with IC50 value of 63.0 ± 3.2 μM.Graphical abstract

Source: Phytochemistry Letters - February 21, 2020 Category: Chemistry Source Type: research