Synthesis, Structural Characterization and Antiproliferative Activity on MCF-7 and A549 Tumor Cell Lines of [Cu(N-N)(β3-aminoacidate)]NO3 Complexes (Casiopeínas®)

Publication date: Available online 19 February 2020Source: Inorganica Chimica ActaAuthor(s): Jonathan Román Valdez-Camacho, Yaquelinne Pérez-Salgado, Adrián Espinoza-Guillén, Virginia Gomez, Carlos Alberto Tavira-Montalvan, Angélica Meneses-Acosta, Marco A. Leyva, María G. Vázquez-Ríos, Eusebio Juaristi, Herbert Höpfl, Lena Ruiz-Azuara, Jaime EscalanteAbstractThe synthesis of three new mixed chelate copper (II) nitrate coordination compounds of the general formula {[Cu(phen)(L)(solv)]NO3· 0-0.5(solv)} is reported, where phen is 1,10-phenanthroline and L is a β3-aminoacidate (β-alaninate for 1, 3-aminobutanoate for 2 and 3-amino-3-cyclohexylpropanoate for 3), and the solvent (solv) is H2O and/or MeOH. The complexes were characterized by elemental analysis, IR and UV-Vis spectrophotometry, EPR spectroscopy, effective magnetic moment, conductometric and cyclovoltammetric measurements as well as single-crystal X-ray diffraction (SCXRD) analysis. All complexes are mononuclear Cu(II) complexes with d9 configuration. In solution, the compounds are 1:1 electrolytes and exhibit square-based pyramidal coordination polyhedra. Meanwhile, in the solid state the coordination geometries are square-based pyramidal for compounds 1 and 2, but distorted octahedral for compound 3 due to coordination of the nitrate counterion. In vitro studies revealed that compounds 1, 2 and 3 have growth inhibition activity against MCF-7 and A549 tumor cell lines. The clustering of the experimental ...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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