Can combining vaginal and rectal progesterone achieve the optimum progesterone range required for implantation in the HRT-FET model?

Conclusions: Combined rectal and vaginal progesterone in HRT-FET cycles, resulted in high median P4 levels compared to vaginal administration, only. This study suggests that an upper threshold for serum P4 may exist and that too high serum P4 levels may decrease the ongoing pregnancy. Rectally administered progesterone was well tolerated by patients.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research