Interaction of Long Noncoding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss.

Interaction of Long Noncoding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss. Adv Exp Med Biol. 2020;1227:107-129 Authors: Salviano-Silva A, Berti FCB, Lobo-Alves SC, de Araujo-Souza PS, Boldt ABW, Malheiros D Abstract The Notch signaling is a crucial pathway involved in cellular development, progression, and differentiation. Deregulation of Notch signaling pathway commonly impacts tissue homeostasis, being highly associated with proliferative disorders. The long noncoding RNAs (lncRNAs), which are transcripts with more than 200 nucleotides that do not code for proteins, were already described as Notch signaling pathway-interacting molecules. Many of them act as important transcriptional and posttranscriptional regulators, affecting gene expression and targeting other regulatory molecules, such as miRNAs. Due to their strong impact on function and gene expression of Notch-related molecules, lncRNAs influence susceptibility to cancer and other diseases, and can be regarded as potential biomarkers and therapeutic targets. Along this chapter, we summarize the cross talk between the Notch signaling pathway and their most important modulating lncRNAs, as well as the pathological consequences of these interactions, in different tissues. PMID: 32072502 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research