A Transcriptional Signature Accurately Identifies Aspergillus Infection Across Healthy and Immunosuppressed States

Invasive aspergillosis (IA) is a major cause of critical illness in immunocompromised (IC) patients. However, current fungal tests are limited. Disease-specific gene expression patterns in circulating host cells show promise as novel diagnostics, however it is unknown whether such a ‘signature’ exists for IA and the effect of iatrogenic immunosuppression on any such biomarkers.Male BALB/c mice were separated into 6 experimental groups based on Aspergillus fumigatus inhalational exposure and IC status (no immunosuppression, cyclophosphamide, and corticosteroids).

Source: Translational Research - February 19, 2020 Category: Research Authors: Julie M. Steinbrink, Aimee K. Zaas, Marisol Betancourt, Jennifer L. Modliszewski, David L. Corcoran, Micah T. McClain Source Type: research