Ultrasound May ID Children at Risk for Cystic Fibrosis Liver Disease

THURSDAY, Feb. 20, 2020 -- A heterogeneous pattern on ultrasound examination of the liver may help identify children with cystic fibrosis (CF) at increased risk for developing advanced CF liver disease, according to a study published online Feb. 12...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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A heterogeneous liver pattern could indicate a higher risk for advanced cystic fibrosis liver disease
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Gastroenterology, Pathology, Pediatrics, Pulmonology, Radiology, Journal, Source Type: news
Ultrasound can help clinicians identify children with cystic fibrosis (CF)...Read more on AuntMinnie.comRelated Reading: Carbon nanotube tomosynthesis may be better for cystic fibrosis Novel MRI scans could aid in cystic fibrosis CT can replace x-ray for pediatric cystic fibrosis patients Growing radiation dose for CF patients highlights risks MRI still no match for CT in cystic fibrosis
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
To assess if a heterogeneous pattern on research liver ultrasound examination can identify children at risk for advanced cystic fibrosis (CF) liver disease.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
Conclusions: Using modified serum lab thresholds, addition of liver fibrosis indices, and/or abdominal US can increase detection of liver nodularity in CF. A combination of GGT, GPR, and APRI can help direct which CF children should undergo US evaluation. These tools may improve earlier identification of fibrosis and/or cirrhosis in CF patients.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
No abstract available
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Invited Commentaries Source Type: research
Conclusions: Liver US patterns in children with CF correlate with platelet count, spleen size and indices of liver fibrosis. Multivariable models of these biomarkers have excellent discriminating ability for NL versus NOD, and good ability to distinguish other US patterns, suggesting that US patterns correlate with clinically relevant liver disease.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Posters Sessions Source Type: research
(Children's Hospital Colorado) Children's Hospital Colorado (Children's Colorado) pediatric gastroenterologist, Michael Narkewicz, MD, recently shared results of the Prospective Study of Ultrasound to Predict Hepatic Cirrhosis in Cystic Fibrosis (PUSH), which sought to determine if liver ultrasounds could identify children and adolescents with cystic fibrosis who are at greater risk of developing advanced liver disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Liver disease in cystic fibrosis has many causes, with biliary fibrosis due to abnormal CFTR protein predominating. Assessment requires aetiology to be defined. Biliary fibrosis may progress to cirrhosis and portal hypertension, which although initially asymptomatic, may cause varices and splenomegaly. Monitoring progression includes clinical and ultrasound assessment with endoscopic assessment of varices for those at risk. Extrapolated primarily from longitudinal assessment of viral hepatitis in adults, non-invasive elastography has a potential role.
Source: Paediatric Respiratory Reviews - Category: Respiratory Medicine Authors: Tags: The 2017 Royal Society Of Medicine Cystic Fibrosis Symposium Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Welcome to the 322nd LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM. The Most Fair Dinkum Ripper Beauts of the Week The Intensive Care Network have more podcasts from the CICM ASM. A new batch focusi...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Education LITFL review Source Type: blogs
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