C. difficile (C. diff): An urgent threat

Clostridioides (previously Clostridium) difficile (C. diff) is the most common cause of diarrhea among hospitalized patients and the most commonly reported bacteria causing infections in hospitals. In a 2019 report, the CDC referred to C. diff as “an urgent threat.” Who is most at risk? C. diff infection (CDI) occurs more commonly following antibiotic therapy or hospitalization, and among older adults or patients with weakened immune responses. In 2002, an epidemic strain of C. diff emerged, causing more severe disease with inflammation of the colon (colitis) and an increase in deaths. This strain adheres better to the intestine and produces more toxin, which is responsible for causing illness. Non-epidemic strains may cause less severe disease. What makes C. diff so difficult to treat? A high relapse rate poses challenges to treating people with CDI. Recurrence of diarrhea following initial treatment occurs in about 20% of cases. The risk of yet another relapse is even greater in the weeks following treatment for a recurrent CDI. C. diff produces spores (dormant cells capable of surviving harsh conditions for prolonged periods) that can contaminate the environment. Spores are hearty and resistant to routine cleaning. But enhanced protective measures — careful hand washing, isolation precautions for infected patients (private room, gown, and gloves), and cleaning with agents capable of killing C. diff spores — are effective ways to prevent transmission...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Digestive Disorders Health Infectious diseases Prevention Source Type: blogs

Related Links:

Publication date: Available online 5 April 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Alexandre Joosten, Sean Coeckelenbergh, Brenton Alexander, Maxime Cannesson, Joseph Rinehart
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Jeffrey A. SingerAmong the many lessons of the COVID-19 pandemic is how cumbersome one ‐​size‐​fits‐​all regulations, administered by an impersonal bureaucracy, hamper a rapid and flexible response to an evolving public health emergency. The U.S. Navy Medical Corps provides us with the most recent example.On March 30, the naval hospital ship U.S.N.S.Comfortarrived in New York harbor, with 1,000 hospital beds and 1.200 staff, ready to assist in the management of the epidemic which has taken a heavytoll on New York metropolitan area inhabitants. Yet, as of April 3, only20 patients were being treated on ...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
There are roughly 3 million people in the U.S. with opioid use disorder that are now also facing the coronavirus crisis.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
This study summarized and analyzed the monitoring data from 1997, 1999, 2011, 2014, and 2017 of children living in Shanghai. In each monitoring year, the probability-proportional-to-size sampling technique was used to select 30 sampling units. In each sampling unit, one primary school was randomly selected. From each selected school, 40 8-10-year-old children were randomly recruited to measure thyroid volume (Tvol) and their household salt iodine intake. RESULTS: In 1997, 1999, 2011, 2014, and 2017, MUI of 8-10-year-old children was 228 μg/L, 214 μg/L, 1826 μg/L, 171 μg/L and 183 μg/L, and median Tvol (M...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Experts are watching carefully to see if this virus will follow the seasonal pattern of flu, but warn differences may be minorCoronavirus – latest updatesSee all our coronavirus coverageBalmy days are coming, with temperatures forecast to reach 20C in some regions. The warm weather will bring welcome respite to lockdown Britain- and put pressure on authorities trying to control crowds and gatherings.However, scientists also believe warm weather could bring new insights into the virus by showing whether it reacts to the onset of spring. Flu epidemics tend to die out as winter ends; could sunshine, similarly, affect th...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Science Immunology Summer Infectious diseases Epidemics Medical research Microbiology UK news UK weather Health Source Type: news
The CDC ’s overseas epidemic prevention activities, a veritable gift from America to the world, were effectively eviscerated in early 2018 by Trump and the then Republican-controlled Congress in alignment with the White House’s “America First” ideology. This wholesale slaughter on global public heal th preparedness later left China unable to take advantage of the CDC’s expertise […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
Authors: Yao H, Chen JH, Xu YF PMID: 32247261 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
In times of crisis, scientists have to make ethical decisions about new treatments – even if the evidence seems shaky• Laura Spinney is the author of Pale Rider: The Spanish Flu of 1918 and How it Changed the World• Coronavirus latest updates• See all our coronavirus coverageSometimes the parallels between this pandemic and previous ones are uncanny.Take hydroxychloroquine, the anti-malarial drug that regulatory agencies all over the world arenow hastily authorising for the treatment of hospitalised Covid-19 patients. Outside hospitals,Donald Trump and the Brazilian president,Jair Bolsonaro, have expre...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Medical research Infectious diseases Science World news Drugs Flu pandemic Health Society UK news Epidemics France Europe Source Type: news
This study delves into the mechanisms by which a short period of fasting can accelerate wound healing. Fasting triggers many of the same cellular stress responses, such as upregulated autophagy, as occur during the practice of calorie restriction. It isn't exactly the same, however, so it is always worth asking whether any specific biochemistry observed in either case does in fact occur in both situations. In particular, the period of refeeding following fasting appears to have beneficial effects that are distinct from those that occur while food is restricted. Multiple forms of therapeutic fasting have been repor...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We report three cases of acute keratitis in young adults during an epidemic. The epithelial involvement was peripheral, central or diffuse. The outcome was favorable under symptomatic topical treatment. PMID: 32241590 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
More News: Antibiotic Therapy | Blogging | Bronchitis | Centers for Disease Control and Prevention (CDC) | Clindamycin | Clostridium Difficile | Dentistry | Education | Emergency Medicine | Environmental Health | Epidemics | Epidemiology | Eyes | Gastroenterology | Harvard | Health | Hospitals | Infectious Diseases | Metronidazole | Proton Pump Inhibitors PPIs | Study | Transplant Surgery | Transplants | Universities & Medical Training