Collection of Peripheral Blood Progenitor Cells in One Day is Associated with Decreased Donor Toxicity compared to Two Days in Unrelated Donors

The availability of unrelated donors has allowed a significant increase in the numbers of allogeneic transplants. Peripheral blood stem cells (PBSC) has become the most common hematopoietic cell graft source in unrelated donors [1]. This is likely due to perceived decreased donor discomfort and increased donor convenience compared to bone marrow harvests [2]. Currently, the most common method for collecting PBSC in unrelated donors in the U.S. is by filgrastim (Neupogen ®, Amgen, Thousand Oaks, CA, USA) mobilization and apheresis.

Source: Biology of Blood and Marrow Transplantation - February 19, 2020 Category: Hematology Authors: Jack W. Hsu, Bronwen E. Shaw, Soyoung Kim, Brent R. Logan, Jennifer A. Sees, Dennis L. Confer, Michael A. Pulsipher, Nirali Shah, Galen E. Switzer, Muneer H. Abidi, Ibrahim A. Ahmed, Paulo N. Anderlini, Christopher Bredseon, Saurabh Chhabra, Christopher E Source Type: research