Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Publication date: Available online 20 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Ahmad Reza Bagheri, Mehrorang GhaediAbstractThe aim of this study is a present of a simple solvothermal synthesis approach for preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF was fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decrease the extraction time (4 min) and also enhance adsorption capacity (250 mg g−1). Moreover, the magnetic property of presented sorbent (15 emu g−1) accelerate the extraction process which don't need filtration, centrifuge and precipitation pro...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research