Response to Ring: In silico predictive metagenomic analyses highlight key metabolic pathways impacted in the HS skin microbiome

This study included a predictive analysis which utilized a publically-available dataset (Ring et al. 2017) and our dataset that was generated from a prospectively recruited cohort of HS subjects and normal controls (Schneider et al. 2019). These two datasets were generated using the same sequencing method (16S rRNA V3-V4), although the patient demographics, sampling procedures, and body sites sampled varied between them (Table 1a).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research

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Conclusions: IED may be independently associated with HS and may benefit from systemic immunosuppression. PMID: 32255701 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
CONCLUSION: This study has shown that there are significant differences in the treatment between disciplines and countries. On the one hand, the disease severity, on the other hand, individual experience and preferences affect the treatment. Depending on the discipline that determined the therapy, some treatments are provided more rarely or not at all. Revised and up-to-date guidelines embodying all relevant disciplines would be desirable for a standardised therapy. PMID: 32259857 [PubMed - in process]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
This Viewpoint discusses the current understanding about the mechanisms by which inflammation may modify pain perception via central sensitization in hidradenitis suppurativa and stresses the importance of future research into pain perception and management in these patients.
Source: JAMA Dermatology - Category: Dermatology Source Type: research
In conclusion, HS deeply affects patients’ physical and mental status, starting from a very young age. An early intervention is advisable, not only with pharmacological treatment, but also with an appropriate discussion and interaction wit h the patient to focus on the aspects that would reduce the psychosocial impact of their condition.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
AbstractPatient-reported outcome (PRO) measures play an important role in clinical care. Currently, a broad-spectrum, validated PRO measure suitable for all dermatology patients, as part of clinical care, does not exist. Patient-reported Outcome Measures Information System (PROMIS) measures track specific domain outcomes across all diseases. To assess the relevance and utility of a computer-adaptive health assessment consisting of three PROMIS domains in routine dermatologic care. This retrospective study evaluated a PROMIS health assessment, consisting of three computer-adaptive test domains (pain interference, anxiety, a...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
rd FJ Abstract Pain and discomfort are important symptoms in dermatology. The aim of this cross-sectional, multicentre study was to describe the prevalence of pain/discomfort and its associations in patients with several dermatological conditions across 13 European countries. The outcome was the prevalence of pain/discomfort according to a question of the EQ-5D questionnaire. Data collected from November 2011 to February 2013 were complete for 3,509 consecutive outpatients. Moderate or extreme pain/discomfort was reported by 55.5% of patients and 31.5% of controls with no skin conditions. The highest proportions w...
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Rationale: Surgical treatment of hidradenitis suppurativa (HS) is challenging. Wide excision of affected lesions followed by skin graft or flap coverage has been recommended to achieve remission and prevent recurrence. Herein, we present our experience of bilateral inferomedial gluteal defects coverage using symmetrical keystone flaps (KFs) designed parallel to relaxed skin-tension lines (RSTLs). Patient concerns: An 18-year-old man was admitted for chronic inflammatory lesions in both inferomedial gluteal areas. Diagnoses: Physical examination revealed multiple sinuses with broad surrounding scars in both inferome...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 29 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): M.J. Sánchez-Pujol, P. Álvarez-Chinchilla, A. Docampo-Simón, J.C. Pascual Ramírez
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Abstract White fibrous papulosis of the neck is a rare entity, with fewer than 50 cases described. It is a benign pathology whose main interest lies in its broad differential diagnosis, especially with pseudoxanthoma elasticum. The authors report the case of a 77-year-old woman with multiple yellow-white monomorphic papules on the posterior cervical region, with years of evolution. Cutaneous biopsy revealed a nodular area in the superficial and middle reticular dermis, with slight thickening of the collagen fibers and focally enlarged elastic fibers, aspects highlighted in the Verhoeff staining that additionally showed abs...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
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