Response to Ring: In silico predictive metagenomic analyses highlight key metabolic pathways impacted in the HS skin microbiome
This study included a predictive analysis which utilized a publically-available dataset (Ring et al. 2017) and our dataset that was generated from a prospectively recruited cohort of HS subjects and normal controls (Schneider et al. 2019). These two datasets were generated using the same sequencing method (16S rRNA V3-V4), although the patient demographics, sampling procedures, and body sites sampled varied between them (Table 1a).
Condition: Hidradenitis Suppurativa Interventions: Drug: Intralesional Triamcinolone 10 mg/mL; Drug: Intralesional Triamcinolone 20 mg/mL; Drug: Intralesional Triamcinolone 40 mg/mL; Drug: Placebo Sponsor: Montefiore Medical Center Not yet recruiting
Publication date: Available online 7 October 2020Source: The American Journal of SurgeryAuthor(s): Donna Ayala, Chathurika Samudani Dhanasekara, Kyle Thomas, Virginia Tran, Audrey Le, Audrey Hand, Adel Alhaj Saleh, John Griswold, Sharmila Dissanaike
Background: Quality of life (QOL) in hidradenitis suppurativa (HS) patients is negatively impacted by physical and psychosocial problems. The aim of this study was to investigate the frequency and severity of HS-specific symptoms and to correlate these with disease severity. Methods We analyzed medical record data from 145 patients seen in an academic HS specialty clinic between August 2009 to March 2018. Results Hurley stage III patients had significantly higher mean Dermatology Life Quality Index (DLQI) scores (20.2) compared to patients with Hurley stage I (11.3) and II (13.9), (P
Hidradenitis suppurativa (HS) is a debilitating skin condition; in severe forms it requires excision and skin grafting for cure. This is commonly performed as a multi-stage procedure; we explored single-stage operation as a more efficient alternative.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory condition which affects apocrine gland-rich skin.1 It primarily develops in intertriginous areas, including the axilla, groin, perianal, and perineal regions and presents with recurrent, painful nodules, abscesses, draining tunnels, and scarring.1 Despite the continuing research and development of biologics for HS, biologics can lead to the formation of anti-drug antibodies (ADAs) that inactivate the therapeutic effects of the treatment, leading to a decreased drug level and resulting in a suboptimal response.2. PMID: 33006769 [PubMed - as supplied by publisher]
Hidradenitis suppurativa (HS) is a debilitating inflammatory disease where poor healing precludes definitive surgical cure.