Anionic versus neutral Pt(II) complexes: The relevance of the charge for human serum albumin binding.
Anionic versus neutral Pt(II) complexes: The relevance of the charge for human serum albumin binding. J Inorg Biochem. 2020 Feb 11;206:111024 Authors: Ricciardi L, Guzzi R, Rizzuti B, Ionescu A, Aiello I, Ghedini M, La Deda M Abstract The focus of this work is pointing out the different behavior of two structurally related Pt(II) complexes, the anionic cyclometalated NBu4[(Bzq)Pt(Thio)], 1 and the neutral [(Phen)Pt(Thio)], 2, (Bzq = benzo[h]quinoline, Phen = 1,10-phenantroline, Thio = 1,2-benzenedithiolate), on the interaction with human serum albumin (HSA), a key drug-delivery protein in the bloodstream. Being very limited the number of anionic Pt(II) complexes reported to date, this is a pioneering example of report on a protein-ligand interaction involving a negatively charged platinum compound. The study was carried out by using fluorescence spectroscopy, differential scanning calorimetry and molecular docking simulations. The results revealed a strong binding affinity between the anionic compound and the protein, whereas a weak/moderate binding interaction was highlighted for the neutral one. Comparative studies with site specific ligands (warfarin and ibuprofen), allowed us to identify the protein binding sites of the two compounds. The work aims to shed light on the relevance of the charge in designing new drugs with a favorable binding affinity for HSA, which strongly contributes to influence their pharmacological an...
Publication date: Available online 4 April 2020Source: Tribology InternationalAuthor(s): V.S. Mello, E.A. Faria, S.M. Alves, C. Scandian
Publication date: Available online 4 April 2020Source: Radiation Physics and ChemistryAuthor(s): R.S. Omar, S. Hashim, S.K. Ghoshal, D.A. Bradley, N.D. Shariff
A Batavia hospital has submitted plans for a $7.8 million expansion, a re-do on a plan first announced two years ago. The United Memorial Medical Center project includes a 5,000-square-foot imaging department addition to house a new MRI, CT scanner, and additional X-Ray room plus a new morgue. It’s the first phase of a three-phase plan at the 131-bed hospital, which was initially submitted to the state Depart ment of Health this week in an $18 million proposal that went on to receive approvals…
CONCLUSIONS: In Romanian population, the MMC of mandibular first molars, when present, is commonly associated with a second distal canal, unlike the mandibular second molars where the occurrence of a MMC was associated with only one distal canal. When performing the preoperative evaluation, it has also to be considered the patient gender, since the male∕female ratio of MMC was 1:3 in mandibular first molars and 5:1 in mandibular second molars. PMID: 32239106 [PubMed - in process]
CONCLUSION: In the early stage of COVID-19 CRP levels were positively correlated with lung lesions and could reflect disease severity. PMID: 32243911 [PubMed - as supplied by publisher]
CONCLUSION: The septal swell body is a dynamic structure that varies in width over time in close correlation to the inferior turbinates. Further research is required to quantify its relevance as a surgical area of interest. PMID: 32241312 [PubMed - as supplied by publisher]
CONCLUSION: There is a good correlation between the clinical symptoms and lateralisation of hydropic changes on magnetic resonance imaging. Further refinements of imaging techniques and grading system will likely improve the diagnostic accuracy and clinical utilisation of hydrops magnetic resonance imaging. PMID: 32241307 [PubMed - as supplied by publisher]
Publication date: December 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 12Author(s): Diogo Cavaco, Pedro Carmo, João Mesquita, Maurício Scanavacca, Pedro Adragão
To characterize the dorsal ulnar corner fragment with regard to size and morphology using 3-dimensional software and computed tomography (CT) scans, as it presents in low-energy intra-articular distal radius fractures occurring in the female postmenopausal population.
ConclusionOur study estimated the number of stroke patients undergoing CTA for suspected LVO and those eligible for thrombectomy in relation to the population. Numbers were essentially the same throughout the week, and during office and on-call hours. Our data can be used to make adequate staffing plans.