Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Nature Reviews Cardiology, Published online: 20 February 2020; doi:10.1038/s41569-020-0339-2Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism, increased oxidative stress and activation of pro-inflammatory pathways associated with diabetes mellitus, which can induce cardiac remodelling and dysfunction. In this Review, Tan and colleagues discuss the pathogenesis of diabetic cardiomyopathy and describe signalling pathways that might be potential therapeutic targets.

Source: Nature Reviews Cardiology - February 19, 2020 Category: Cardiology Authors: Yi Tan Zhiguo Zhang Chao Zheng Kupper A. Wintergerst Bradley B. Keller Lu Cai Source Type: research