Refining the role of carpal tunnel syndrome in cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research

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Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Tugba Ozsoy-Unubol, Yeliz Bahar-Ozdemir, Ilker Yagci
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 27 March 2020Source: Respiratory Medicine Case ReportsAuthor(s): Peter Chung, Sarah Wheeler, Andrew Fong, Hurth Kyle, Bassam Yaghmour
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
ConclusionsCompared to general population the adjusted prevalence of CTS is higher among elderly men with ATTR; CTS is a prognostic marker in ATTR, independently of cardiac involvement, and precedes CA diagnosis by 5 –9 years. The awareness of this association and time delay offers the possibility of an early pre‐clinical ATTR‐CA diagnosis.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, we provide novel insights regarding the molecular basis of ATTRm and ATTRwt based on large-scale cohort, expanding our understanding of the phenotypic spectrum associated withTTR gene variation.
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsHere we report the case of a patient with hereditary cardiac amyloidosis associated with a Pro24Ser mutation in transthyretin, which is the first case reported in Japan. Technetium pyrophosphate scintigraphy was extremely useful for definitive diagnosis. Thus, we propose that the nuclear imaging technique should be taken into account even for an exploratory diagnosis of transthyretin cardiac amyloidosis.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSIONS: Both men and women develop a carpal tunnel syndrome caused by ATTR amyloid. In particular, at the age of over 50 years, amyloid deposits should be considered in the context of the etiological clarification of the carpal tunnel syndrome. Early histological diagnosis is highly relevant to identify the risk of cardiac amyloidosis. For an early and correct diagnosis of ATTR amyloidosis, histological examination of the flexor retinaculum is particularly necessary, and a sample excision should always be obtained and examined histologically. PMID: 30404120 [PubMed - in process]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
CONCLUSIONS: Diagnosis of ATTR amyloidosis should be suspected in patients with late onset severe hypertrophic cardiomyopathy. Val122Ile mutation can also be found in Caucasian individual. A mild to severe small and large fiber sensory and autonomic neuropathy is frequently associated as well as carpal tunnel syndrome. Tafamidis oral treatment or combined liver and heart transplant are current therapeutic options in these patients. Prognosis ATTR-Val122Ile is linked to the prominent cardiac amyloidosis. Early diagnosis is desirable. Study Supported by:Disclosure: Dr. Salhi has nothing to disclose. Dr. Lefaucheur has nothin...
Source: Neurology - Category: Neurology Authors: Tags: Neuropathy: Pathogenesis and Pathology Source Type: research
In conclusion: the Swedish TTRHis88Arg patients all have a common Swedish founder. Cardiomyopathy with heart failure, as well as carpal tunnel syndrome and spinal stenosis were early signs of disease; but peripheral neuropathy was present in one patient before symptoms of cardiomyopathy so the phenotypical presentation of this mutation is variable. PMID: 25721874 [PubMed - as supplied by publisher]
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
More News: Amyloidosis | Cardiology | Carpal Tunnel Syndrome | Heart | Heart Failure