Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups.

Source: Journal of Neuroimmunology - February 19, 2020 Category: Allergy & Immunology Authors: Simon Faissner, Florian Graz, Sabrina Reinehr, Laura Petrikowski, Steffen Haupeltshofer, Ula ş Ceylan, Gesa Stute, Stephan Winklmeier, Florence Pache, Friedemann Paul, Klemens Ruprecht, Edgar Meinl, H. Burkhard Dick, Ralf Gold, Ingo Kleiter, Stephanie C. Source Type: research