The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability: A mini-review

Publication date: Available online 19 February 2020Source: Chinese Chemical LettersAuthor(s): Min Sun, Hankun Hu, Leming Sun, Zhen FanAbstractOral administration has been widely regarded as the most convenient, quick and safe approach compared to other routes of drug delivery. However, oral absorption of drugs is often limited due to rigorous environments and complex obstacles in gastrointestinal tract. Having received considerable attention, biomacromolecules have been applied for oral drug delivery to improve the bioavailability, which could be attributed to its stability and unique bioactivities, including intestinal adhesion, opening of epithelial tight junctions, inhibiting cell efflux and regulating relative protein expression. Specifically, enhancing intestinal permeability has been regarded as a promising strategy for improving bioavailability of oral drug delivery. In this review, a series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated. In addition, recent advances in biomacromolecules based oral delivery and related future directions are mentioned and predicted in this review article.Graphical AbstractRecent advances of various biomacromolecules in enhancing oral delivery efficiency by promoting intestinal permeability are reviewed, and their respective mechanisms are summarized to guide the use of biomacromolecules in oral administration.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research