Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors

Conditions:   Advanced Solid Tumors;   MSI-H/dMMR Tumors;   Cutaneous Squamous Cell Carcinoma;   Urothelial Carcinoma, HCC;   Cervical Cancer;   Esophageal Squamous Cell Carcinoma;   Merkel Cell Carcinoma, Small-cell Lung Cancer;   Mesothelioma;   PD-L1 Amplified Tumor (9p24.1);   Nasopharyngeal Carcinoma;   Cyclin-dependent Kinase 12 Mutated Tumors;   Basal Cell Carcinoma (Unresectable or Metastatic);   Sarcomatoid Renal Cell Carcinoma;   Clear Cell Ovarian or Endometrial Carcinoma;   Anal Carcinoma;   Squamous Cell Penile Carcinoma;   DNA Polym erase Epsilon Mutated Tumors (P286R and V411L) Intervention:   Drug: INCB099318 Sponsor:   Incyte Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We report the case of a 48 ‐year‐old man who presented with persistent right‐sided thoracic pain with chest computed tomography scan demonstrating a right‐sided pleural effusion and pleural mass invading the ribs. Ultrasound‐guided biopsy revealed a primary squamous cell carcinoma of the pleura. Positron emission to mography staging demonstrated metastatic lung and lymph node involvement precluding surgical therapy. Immunotherapy with nivolumab resulted in prolongation of survival with good quality of life. Malignant pleural effusions usually manifest in the course of metastatic cancer disease. Primary pleural tu...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Conditions:   Advanced Solid Tumor;   MSI-H/dMMR Tumors;   Cutaneous Squamous Cell Carcinoma;   Urothelial Carcinoma;   Cervical Cancer;   HepatoCellular Carcinoma;   Esophageal Squamous Cell Carcinoma;   Merkel Cell Carcinoma;   Small-cell Lung Cancer;   Mesothelioma;   PD-L1 Ampli fied Tumor (9p24.1);   Nasopharyngeal Carcinoma Intervention:   Drug: INCB099280 Sponsor:   Incyte Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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