Coronavirus: Niti CEO to find ways to reduce drug import dependence on China

The list has been compiled by the drug regulatory authority and contains antibiotics like azithromycin, amoxicillin, ofloxacin, metronidazole, vitamins such as B12, B1, B6 and E, female hormone progesterone and anticardiac arrest drug atorvastatin, among others.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news

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Acute respiratory distress syndrome is a heterogenous syndrome with many etiologies for which there are no definitive pharmacologic treatments, despite decades of research. We explore some adjunctive pharmacologic therapies, including neuromuscular blockade, corticosteroids, and inhaled pulmonary vasodilators. Additionally, we explore some investigative therapies, including Vitamin C, beta-agonists, statins, mesenchymal stromal cells, and granulocyte –macrophage colony stimulating factor. We do discuss the potential role of steroids in acute respiratory distress syndrome with severe acute respiratory syndrome coronav...
Source: Critical Care Clinics - Category: Intensive Care Authors: Source Type: research
Coronavirus disease 2019 (COVID-19) pandemic is caused by the novel coronavirus that has spread rapidly around the world, leading to high mortality because of multiple organ dysfunction; however, its underlying molecular mechanism is unknown. To determine the molecular mechanism of multiple organ dysfunction, a bioinformatics analysis method based on a time-order gene co-expression network (TO-GCN) was performed. First, gene expression profiles were downloaded from the gene expression omnibus database (GSE161200), and a TO-GCN was constructed using the breadth-first search (BFS) algorithm to infer the pattern of changes in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsThe study suggested sex differences in the risk of death from COVID-19 with the use of ACEI and ARB among middle-aged and older adults. Sex differences in the risk of hospitalization for COVID-19 with the use of CCB was observed as well. It is of clinical importance that clinicians adopt different CVD treatment approaches for female and male patients with COVID-19.
Source: Drugs and Aging - Category: Geriatrics Source Type: research
The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory coronavirus  2 (SARS-CoV-2), remains a major public health problem across the globe, despite the availability of vaccines (Hamed et al., 2021). Consequently, there is a continuing need for effective pharmacological therapies that reduce the morbidity and mortality of patients with COVID-19.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
The current coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory coronavirus-2 (SARS-CoV-2), remains a major public health problem across the globe, despite the availability of vaccines (Hamed et al., 2021). In the meantime, we continue to need effective pharmacological therapies that reduce the morbidity and mortality of patients with COVID-19.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
ConclusionStatin use is associated with a better prognosis in patients with COVID-19. Our findings provide a rationale to investigate the use of statins among patients with COVID-19 in large scale clinical  trials.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
Purpose of review Coronavirus Disease 2019 (COVID19) has caused significant global morbidity and mortality, especially in persons with underlying cardiovascular disease. There have been concerns that lipid-lowering therapy (LLT) increases angiotensin-converting enzyme 2 levels. Conversely, pleiotropic effects of statins can theoretically protect against severe COVID19 infection, supporting evidence from other respiratory illnesses in which statin use probably confers benefit. Recent findings There is an abundance of studies that show that statins are safe and potentially protect against severe COVID19 infection ...
Source: Current Opinion in Lipidology - Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research
Publication date: Available online 5 July 2021Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Jeremy Rafael Tandaju, Wang Ii, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Abstract: Statin therapy has been recently suggested as possible adjuvant treatment to improve the clinical outcome in patients with coronavirus disease 2019 (COVID-19). The aim of this study was to describe the prevalence of preadmission statin therapy in hospitalized patients with COVID-19 and to investigate its potential association with acute distress respiratory syndrome (ARDS) at admission and in-hospital mortality. We retrospectively recruited 467 patients with laboratory-confirmed COVID-19 admitted to the emergency department of 10 Italian hospitals. The study population was divided in 2 groups according to the...
Source: Journal of Cardiovascular Pharmacology - Category: Cardiology Tags: Original Article Source Type: research
Publication date: Available online 29 June 2021Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Timotius Ivan Hariyanto, Andree Kurniawan
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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