miRNA-411 Regulates Chondrocyte Autophagy in Osteoarthritis by Targeting Hypoxia-Inducible Factor 1 alpha (HIF-1 α).

CONCLUSIONS Our results demonstrate that miR-411 promotes chondrocyte autophagy by targeting HIF-1alpha, suggesting that regulating HIF-1alpha by miR-411 might be a therapeutic strategy for OA. PMID: 32072994 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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Conclusion: The current review identified strong, high-quality evidence to recommend hip muscle strengthening in the conservative management of persons with knee OA. Further research is needed to establish the underlying mechanisms for the clinical benefits.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Systematic Reviews Source Type: research
Publication date: Available online 30 March 2020Source: Journal of Orthopaedic TranslationAuthor(s): Lawrence C.-M. Lau, Jason C.-H. Fan, Kwong-Yin Chung, Kin-Wing Cheung, Gene C.-W. Man, Yuk-Wah Hung, Carson K.-B. Kwok, Kevin K.-W. Ho, Kwok-Hing Chiu, Patrick S.-H. Yung
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Conditions:   Osteoarthritis, Knee;   Knee Replacement Intervention:   Behavioral: Mindfulness-based Cognitive Behavioral Therapy Sponsor:   Brigham and Women's Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
To assess the 24-month cost-effectiveness of supervised treatment compared to written advice in knee osteoarthritis (OA).
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research
Meniscal tears are commonly observed on MRIs obtained in middle-aged and older adults, with some studies suggesting a 35% prevalence in the 50-and-older population (1). Not all tears are symptomatic, but patients with these tears often seek treatment when they experience pain, swelling, or interference with valued activities. Physical therapy (PT) and arthroscopic partial meniscectomy (APM) are among the treatment options available to these patients, with clinical trials showing similar benefits in terms of pain and functional improvement for both (2).
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Editorial Source Type: research
This study assessed whether MBBF in the femoral neck (FN) is preserve d in the context of inhibited remodeling in subjects receiving denosumab.This open ‐label study enrolled postmenopausal women with osteoporosis who had received ≥2 doses of denosumab (60 mg subcutaneously Q6M) per standard of care and were planning elective total hip replacement (THR) owing to osteoarthritis of the hip. Transverse sections of the FN were obtained after THR and analyzed histomorphometrically. MBBF, based on fluorochrome labeling and presence of smooth cement lines, was evaluated in cancellous, endocortical, and periosteal envelopes o...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
Condition:   Hip Osteoarthritis Intervention:   Device: Surgery Sponsor:   Zimmer Biomet Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Interventions:   Biological: Autologous Mesenchymal Stem Cells Treatment (MSCs);   Drug: Hyaluronic acid (HA) Sponsor:   Chinese University of Hong Kong Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pain Reduction;   Physical Function Improvement Interventions:   Drug: 25 mg/week oral methotrexate tablets;   Drug: 25mg/week oral placebo tablets Sponsor:   University of Alexandria Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Hip Osteoarthritis Intervention:   Device: Surgery Sponsor:   Zimmer Biomet Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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