Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

In this study we investigated the therapeutic efficacy of ACT with liposomal doxorubicin for the treatment of triple negative breast cancer using orthotopic human tumor xenografts (MDA-MB-231-H.luc) in athymic mice (ICR-NCr-Foxn1nu). Doxil® (6 mg/kg, i.v.) was administered at days 0 and 21, each time immediately followed by three sequential ACT (20 ml/kg PS101) treatment procedures (n = 7–10). B-mode and nonlinear ultrasound images acquired during the activation phase were correlated to the therapeutic efficacy.ResultsResults show that combination with ACT induces a strong increase in the therapeutic efficacy of Doxil®, with 63% of animals in complete, stable remission at end of study, vs. 10% for Doxil® alone (p
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Condition:   Breast Cancer Interventions:   Diagnostic Test: Serum Autotaxin;   Radiation: chest x-ray;   Diagnostic Test: Breast ultrasound or mammography;   Diagnostic Test: Histopathological examination of breast mass specimens;   Radiation: Magnetic Resonance Imaging ( MRI) and Bone scan;   Diagnostic Test: Peripheral  haemogram;   Diagnostic Test: Renal and liver functions;   Diagnostic Test: Prothrombin time and concentration;   Diagnostic Test: Cancer Antigen...
Source: - Category: Research Source Type: clinical trials
AbstractBreast cancer is the leading killer of Chinese women. Immunohistochemistry index has great significance in the treatment strategy selection and prognosis analysis for breast cancer patients. Currently, histopathological examination of the tumor tissue through surgical biopsy is the gold standard to determine immunohistochemistry index. However, this examination is invasive and commonly causes discomfort in patients. There has been a lack of noninvasive method capable of predicting immunohistochemistry index for breast cancer patients. This paper proposes a machine learning method to predict the immunohistochemical ...
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
CONCLUSION: CEUS demonstrated good sensitivity in detecting breast cancer, and the combined use with MRI can optimize the diagnostic specificity and accuracy in breast cancer prediction. ADVANCES IN KNOWLEDGE: Few studies have compared the diagnostic efficacy of CEUS and MRI, and this study is the first attempt to seek out the diagnostic values for breast lesions of variable sizes (lesions with ≤20 mm and>20 mm). PMID: 32216631 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Shortened protocol identifies more cancers than ultrasound or mammography.
Source: Diagnostic Imaging - Category: Radiology Authors: Tags: Breast Cancer Breast Health Ultrasound Breast Imaging Mammography MRI Screening Source Type: news
Diagnostic mammography is effective on its own for evaluating palpable breast...Read more on AuntMinnie.comRelated Reading: Ultrasound performance mixed in breast cancer survivors Deep-learning algorithm helps assess dense breasts Supplemental dense breast screening practices vary WISDOM breast cancer screening study now open to all Hey, Alexa -- Tell me about breast density
Source: Headlines - Category: Radiology Source Type: news
Invasiveness research is an essential step in breast cancer metastasis. The application of high-frequency ultrasound microbeam stimulation (HFUMS) offers a manner of determining the invasion potential of human breast cancer cells by eliciting the elevation of transient cytoplasmic calcium ions (Ca2+). The fluorescent index (FI), which is a composite parameter reflecting calcium elevations elicited by HFUMS, was shown to be higher in invasive breast cancer cells (MDA-MB-231) compared to weakly invasive breast cancer cells (MCF-7) using the low-intensity 50-MHz HFUMS. This novel finding shows significant difference from the ...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The proposed imaging method can provide accurate and localized estimation of VP in cancers non-invasively and cost-effectively. Significance: Accurate and non-invasive assessment of VP can have a significant impact on diagnosis, prognosis, and treatment of cancers.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Boguševičius A Abstract Background and objectives: With improved diagnostic means of early breast cancer, the percentage of cases with metastasis in axillary lymph nodes has decreased from 50%-75% to 15%-30%. Lymphadenectomy and sentinel lymph node biopsy are not treatment procedures, as they aim at axillary nodal staging in breast cancer. Being surgical interventions, they can lead to various complications. Therefore, recently much attention has been paid to the identification of non-invasive methods for axillary nodal staging. In many countries, ultrasound is a first-line method to evaluate axillary lym...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Young women with breast cancer often experience financial difficulties after...Read more on AuntMinnie.comRelated Reading: Ultrasound performance mixed in breast cancer survivors Supplemental dense breast screening practices vary 10-minute breast MRI scan beats DBT for invasive cancer Breast screening reduces race-related cancer disparities Most cysts found on breast ultrasound don't need biopsy
Source: Headlines - Category: Radiology Source Type: news
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