Clinical Snippets

Although genetic factors contribute to hidradenitis suppurativa, the etiology of this chronic skin disease that responds to treatment with the tumor necrosis factor inhibitor adalimumab remains undefined. Liu et  al. performed a genome-wide association study of 7 million genetic variants to identify those associated with adalimumab response. These investigations revealed that the single nucleotide variant rs5932114 in the intron of the BCL2 gene is associated with increased expression of BCL2 in hair outer root sheath cells and with adalimumab response.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research