T follicular helper and T follicular regulatory cells in colorectal cancer: A double-edged sword.

T follicular helper and T follicular regulatory cells in colorectal cancer: A double-edged sword. J Immunol Methods. 2020 Feb 13;:112753 Authors: Hetta HF, Elkady A, Yahia R, Meshaal AK, Saad MM, Mekky MA, Al-Kadmy IMS Abstract Colorectal cancer is considered to be one of the major causes of morbidity and mortality all over the world. The recent discovery of T Follicular helper (TFR) and T follicular regulatory (TFH) which are two opposite subsets of follicular T cells that have been demonstrated to be involved in the process of tumorigenesis. CXCR5+CD4+ follicular T helper cells (TFH) are specialized B cell stimulators. On the other hand, CD4+CXCR5+Foxp3+ follicular regulatory T cells (TFR) cell subset can control humoral immune response by suppressing TFH-mediated B-cell activation and antibody production via PD-1 receptor which is highly expressed on its surface. Although, many studies reported the implication of TFH and TFR in human colorectal cancer, their functional role in human colorectal cancer (CRC) is relatively unknown. Under the control of certain cytokines and B-cell lymphoma 6 transcription factor (Bcl-6); the major transcription factor of TFH cells; TFH can expand to the other distinct CD4 + T helper cells (TH1, TH2 and TH17) which exert different role in the development of CRC. The aim of this review is to discuss these suggested roles of the two-opposite subset of follicular T cells in the colorectal cancer immune-p...
Source: Journal of Immunological Methods - Category: Allergy & Immunology Authors: Tags: J Immunol Methods Source Type: research