CD38: Modulating Histone Methyltransferase EZH2 Activity in SLE.

CD38: Modulating Histone Methyltransferase EZH2 Activity in SLE. Trends Immunol. 2020 Feb 12;: Authors: Chakraborty P, Mehrotra S Abstract To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8+ T cell function and might be targeted to overcome incidence of infections. PMID: 32061543 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32061543?dopt=Abstract

Source: Trends in Immunology - February 11, 2020 Category: Allergy & Immunology Authors: Chakraborty P, Mehrotra S Tags: Trends Immunol Source Type: research

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