A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

ConclusionsWe uncovered shared nuclear topographies of cognitive and metabolic risk variants. More broadly, our PsychENCODE sponsored Hi-C study offers a novel genomic approach for the study of psychiatric and medical co-morbidities constrained by limited overlap of their respective genetic risk architectures on the linear genome.

http://link.springer.com/10.1186/s13073-020-0715-x

Source: Genome Medicine - February 18, 2020 Category: Genetics & Stem Cells Source Type: research